有机组分在大气颗粒物（PM）中的吸入生物可接触性和呼吸道沉积是准确估计健康风险和理解人体暴露的关键因素。本研究评估了中国大城市中不同尺寸PM中多环芳烃（PAHs）和PAH衍生物、邻苯二甲酸酯（PAEs）、多氯联苯（PCBs）和有机磷阻燃剂（OPFRs）的体外吸入生物可接触性。在加热期（HP）中，生物可接触性范围为0.2%至77.8%；在非加热期（NHP）中，生物可接触性范围为0.7%至94.2%。结果表明，亲水性较弱的有机物的生物可接触性可能更高。尺寸大于0.65 µm的中等logKow有机物的生物可接触性受高碳分数的抑制，指示共同效应。然后，这是第一项探索源对有机物吸入生物可接触性影响的研究。在HP期间，煤炭和生物质燃烧，NHP期间，交通排放与生物可接触性呈负相关。二次颗粒物也与中等logKow有机物的生物可接触性呈负相关。在考虑了生物可接触性和沉积效率后，对PM10中所有测量组分估计了寿命癌症风险（ILCR）和非癌症风险（HQ），HQ和ILCR都在可接受范围内。BaP和DEHP分别是HQ和ILCR的主要影响因素。版权所有 © 2023 Elsevier B.V. 发布。

Inhalation bioaccessibility and deposition in respiratory tracts of organic components in atmospheric particulate matter (PM) are key factors for accurately estimating health risks and understanding human exposures. This study evaluated the in-vitro inhalation bioaccessibility of polycyclic aromatic hydrocarbons (PAHs) and PAH derivatives, phthalic acid esters (PAEs), polychlorinated biphenyls (PCBs), and organophosphate flame retardants (OPFRs) in size-resolved PM from a Chinese megacity. The bioaccessibility ranged from 0.2% to 77.8% in the heating period (HP), and from 0.7% to 94.2% in the non-heating period (NHP). Result suggests that less hydrophobic organics might be more bioaccessible. Bioaccessibility of medium logKow organics in sizes > 0.65 µm was significantly inhibited by high carbon fractions, indicating the co-effects. Then, this is the first study to explore effects of sources on inhalation bioaccessibility of organics. Coal and biomass combustion in HP and traffic emission in NHP negatively correlated with bioaccessibility. Secondary particles also negatively correlated with bioaccessibility of medium logKow organics. Incremental lifetime cancer risk (ILCR) and non-cancer risk (HQ) for all measured components in PM10 were estimated after considering the bioaccessibility and deposition efficiencies and the HQ and ILCR were within the acceptable range. BaP and DEHP were strong contributors to HQ and ILCR, respectively.Copyright © 2023. Published by Elsevier B.V.