免疫记忆能够在身体重新遇到细菌或病毒株，或者在健康细胞中遇到类似突变时，快速发展免疫防御力。免疫检查点分子程序性细胞死亡1（PD-1）影响记忆T细胞的分化。然而，PD-1调控记忆T细胞发育和维持的机制以及其对记忆T细胞功能的影响仍不清楚。本综述首先讨论了PD-1的结构和功能，然后总结了PD-1作为肿瘤记忆T细胞标志物和肿瘤免疫治疗中的作用。我们还讨论了PD-1在病毒感染介导的疾病、银屑病和类风湿性关节炎等免疫疾病中调节记忆T细胞发育和维持的潜在机制，并列举了PD-1在妊娠期记忆T细胞上的作用以及它们在母胎免疫平衡中的功能。对于PD-1如何影响记忆T细胞的发育、维持和功能的全面理解将为预防和治疗与免疫相关的疾病提供新的见解。版权所有 © 2023 Elsevier B.V. 出版。

Immunological memory helps the body rapidly develop immune defense when it re-encounters a bacterial or viral strain or encounters a similar mutation in healthy cells. The immune checkpoint molecule programmed cell death 1 (PD-1) influences memory T cell differentiation. However, the mechanism by which PD-1 regulates the development and maintenance of memory T cells and its impact on memory T cells function remain unclear. In this review, we first discuss the structure and function of PD-1 and then summarize the roles of PD-1 as a marker of tumor memory T cells and in tumor immunotherapy. We also discuss the potential mechanisms through which PD-1 regulates memory T cells development and maintenance during immune diseases such as viral infection-mediated diseases, psoriasis, and rheumatoid arthritis, and list the effects of PD-1 on memory T cells in pregnancy and their function in maternal-fetal immune balance. A complete understanding of how PD-1 influences the development, maintenance, and function of memory T cells will provide new insights into the prevention and treatment of immune-related diseases.Copyright © 2023. Published by Elsevier B.V.