钌金属树状聚合物对小鼠三阴性乳腺癌的作用。
Ruthenium metallodendrimer against triple-negative breast cancer in mice.
发表日期：2023 Aug 15
作者：
Sylwia Michlewska, Dagmara Wójkowska, Cezary Watala, Elżbieta Skiba, Paula Ortega, Francisco Javier de la Mata, Maria Bryszewska, Maksim Ionov
来源：
Nanomedicine
摘要：
基于苯乙烯二蛇环金属树状聚合物，以基于烯基二磺醇钌(II)配合物（CRD13）为基础，通过嵌入肟吡啶表面基团的方法，在三阴性乳腺癌小鼠模型中作为一种抗癌剂进行研究。该树状聚合物有效地进入细胞，并在4T1细胞中显示出选择性毒性。体内研究证明，CRD13的局部注射导致肿瘤质量减少且不具毒性。ICP分析表明，钌(II)在所有测试组织中积累，并在肿瘤中检测到更高的含量。版权所有 © 2023 。由Elsevier公司出版。
Carbosilane metallodendrimers, based on the arene Ru(II) complex (CRD13) and integrated to imino-pyridine surface groups have been investigated as an anticancer agent in a mouse model with triple-negative breast cancer. The dendrimer entered into the cells efficiently, and exhibited selective toxicity for 4T1 cells. In vivo investigations proved that a local injection of CRD13 caused a reduction of tumour mass and was non-toxic. ICP analyses indicated that Ru(II) accumulated in all tested tissues with a greater content detected in the tumour.Copyright © 2023. Published by Elsevier Inc.