姜黄素（CUR）是治疗癌症的天然和有效的抗肿瘤药物之一。这些药物溶解度低，半衰期短，降低了在药物释放系统中的有效性。本文通过水-油-水（W/O/W）双重纳米乳液法制备了含有壳聚糖（CS）、氧化铝（γ-Al2O3）和碳量子点（CQDs）的水凝胶纳米载体。动态光散射显示纳米载体尺寸为227 nm，ζ电位为-37.8 mV，表示其稳定性。FE-SEM显示其准球形状，傅里叶红外光谱和X射线衍射确认了纳米复合材料中所有组分的存在，并提供了它们之间的分子间相互作用和纳米载体的晶体性质方面的信息。药物负载量（48 %）和封装效率（86 %）高于其他CUR纳米载体之前报道的数值。药物释放剖面显示受控和稳定的释放，以及酸环境中更快的CUR释放的pH敏感行为。通过细胞毒性和细胞凋亡分析，检测了乳腺癌细胞系。结果表明，随着时间的推移，缓慢释放和程序化细胞死亡是CUR与纳米载体之间的相互作用所导致的。考虑到本文获得的结果，CS/γAl2O3/CQDs/CUR可以被认为是一种用于肿瘤治疗的有前景的新型纳米系统。版权所有 © 2023. Elsevier B.V.出版

Curcumin (CUR) is among the most natural and effective antitumor drugs for cancer treatment. These drugs have low solubility and short half-lives that reduce their effectiveness in drug release systems. Herein, a hydrogel nanocarrier containing chitosan (CS), alumina (γ-Al2O3), and carbon quantum dots (CQDs) was prepared by the water-in-oil-in-water (W/O/W) double nanoemulsion method. DLS revealed a nanocarrier size of 227 nm, with a zeta potential of -37.8 mV, which corroborates its stability. FE-SEM showed its quasi-spherical shape, FT-IR and XRD confirmed the presence of all the components in the nanocomposite and gave information about the intermolecular interactions between them and the crystalline nature of the nanocarrier, respectively. The drug loading (48 %) and entrapment efficiency (86 %) were higher than those reported previously for other CUR nanocarriers. The drug release profile revealed a controlled and stable release, and a pH-sensitive behavior, with faster CUR release in an acid environment. The breast cancer cell line was examined by cytotoxicity and cell apoptosis analyses. The results showed that the slow release over time and the programmed cell death were due to interactions between CUR and the nanocarrier. Considering the results obtained herein, CS/γAl2O3/CQDs/CUR can be considered as a promising new nanosystem for tumor treatment.Copyright © 2023. Published by Elsevier B.V.