本研究旨在识别和比较与父母打算为12岁以下女儿接种人类乳头瘤病毒(HPV)疫苗相关的特征和因素， 并检视2016年和2020年的数据。数据来源于2016年和2020年韩国国家癌症筛查调查。本研究纳入了3,510名有12岁以下女儿的父母。计算了父母打算接种疫苗的比例变化。为了识别与父母打算为女儿接种疫苗相关的因素，采用了卡方检验和 logistic 回归分析。打算为女儿接种疫苗的受访者比例从2016年的33.4%增加到2020年的58.9%，增幅为25.5个百分点(p)。自2016年以来，男性参与者对HPV疫苗的积极意愿比例增加了31.5个百分点(p)，而女性参与者的积极意愿比例增加了20.9个百分点(p)。逻辑回归分析表明，打算为女儿接种疫苗的父母往往年龄较小，受教育程度较高，知道有免费疫苗接种计划，并且有接种HPV疫苗的历史以及在过去2年内进行过宫颈癌筛查，相较于不打算接种的人群。作为一名有接种HPV疫苗历史的母亲是积极意愿为女儿接种疫苗的最强预测因子。尽管积极意愿逐渐增加，但父母打算为女儿接种疫苗的比例仍然相对较低。为了提高HPV疫苗接种率，应向父母和年轻一代提供强烈的推荐和教育。

We aimed to identify and compare the characteristics and factors associated with parental intention to vaccinate daughters under 12 years old against human papillomavirus (HPV), examining data from 2016 and 2020.Data were obtained from the Korean National Cancer Screening Survey conducted in 2016 and 2020. The present study included 3,510 parents with daughters under 12 years old. Changes in parental intention-to-vaccinate rates were calculated. To identify factors associated with parental intention to vaccinate their daughters, the chi-square test and logistic regression analysis were used.The percentage of respondents intending to vaccinate their daughters increased from 33.4% in 2016 to 58.9% in 2020, constituting a 25.5 percentage point (%p) increase. Since 2016, the proportion of male participants expressing positive intention towards HPV vaccination increased by 31.5%p, while that of female participants demonstrated a 20.9%p increase. Logistic regression analysis indicated that parents with a strong intention to vaccinate their daughters tended to be younger, more educated, and aware of the free vaccination program available, as well as to have a history of HPV vaccination and to have undergone cervical cancer screening within 2 years, compared to those who did not intend to vaccinate. Being a mother with a history of HPV vaccination was the strongest predictor of positive intention to vaccinate a daughter.The intention among parents to vaccinate daughters remains relatively low, although it is rising. To increase the HPV vaccination rate, strong recommendations and education should be provided to parents and the younger generation.