为了补充密歇根大学（University of Michigan，UM）精准健康队列的电子健康记录（EHR）和基因型信息，建立了流行病学问卷（EPI-Q）用于收集广泛、统一、自我报告的健康数据。EPI-Q参与者的招募从2020年3月开始，他们已经在UM精准健康的三个正在进行的队列——密歇根基因组计划、精神健康生物库以及代谢、内分泌和糖尿病队列中登记入册。共发出了54,043份回顾式邀请，其中5,577人参加，响应率为10.3%。其中，3,502人（63.7%）为女性，平均年龄为56.1岁（标准差为15.4岁）。基线调查包括11个模块，涵盖个人及家族健康史、生活方式、癌症筛查和病史等主题。另外，还设置了11个可选模块，包括财务压力、职业暴露和生活意义等主题。这些问题基于其他队列中使用的标准化和验证过的工具，我们共享资源，以加速类似调查的开发。数据通过“我的数据协助”（MyDataHelps）平台收集，该平台使当前和未来的参与者能够共享非密歇根医学中心的EHR数据。招募工作仍在进行中。经过机构审查委员会批准后，队列数据可供使用；详情请联系临床与转化研究数据办公室（Data Office for Clinical and Translational Research，联系方式：DataOffice@umich.edu，电话：734-615-2100）。

The Epidemiologic Questionnaire (EPI-Q) was established to collect broad, uniform, self-reported health data to supplement electronic health record (EHR) and genotype information from participants in the University of Michigan (UM) Precision Health cohorts. Recruitment of EPI-Q participants, who were already enrolled in 1 of 3 ongoing UM Precision Health cohorts-the Michigan Genomics Initiative, Mental Health Biobank, and Metabolism, Endocrinology, and Diabetes cohorts-began in March 2020. Of 54,043 retrospective invitations, 5,577 individuals enrolled, representing a 10.3% response rate. Of these, 3,502 (63.7%) were female, and the average age was 56.1 years (standard deviation, 15.4 years). The baseline survey comprises 11 modules on topics including personal and family health history, lifestyle, and cancer screening and history. Additionally, 11 optional modules cover topics including financial toxicity, occupational exposure, and life meaning. The questions are based on standardized and validated instruments used in other cohorts, and we share resources to expedite development of similar surveys. Data are collected via the MyDataHelps platform, which enables current and future participants to share non-Michigan Medicine EHR data. Recruitment is ongoing. Cohort data are available to those with institutional review board approval; for details, contact the Data Office for Clinical and Translational Research (DataOffice@umich.edu; (734) 615-2100).