循环RNA（circRNA）是由预前mRNA反向剪接产生的非编码RNA（ncRNA），其特点是5'端缺乏帽子结构，3'端具有多聚腺苷酸尾。近年来，随着RNA测序和生物信息学方法的发展，circRNA的重要临床价值逐渐被揭示。Circ_0067934是位于3q26.2染色体上的一个由PRKCI（蛋白激酶C“Iota”）的外显子15和16反向剪接形成的长度为170个核苷酸的RNA分子。最近的研究发现，在各种肿瘤中circ_0067934的上调或下调与肿瘤大小、TNM分期和预后不良相关。基于癌细胞实验，过表达或沉默circ_0067934会促进癌细胞的增殖、迁移活性和侵袭。可能的机制包括circ_0067934与miRNAs（miR-545、miR-1304、miR-1301-3p、miR-1182、miR-7和miR-1324）结合来调节基因的转录后表达。其他机制包括抑制Wnt/β-连环蛋白和PI3K/AKT信号通路。在本文中，我们总结了circ_0067934在不同肿瘤中的生物学功能和可能的机制，以促进进一步探索其在临床诊断、治疗和预后评估中的转化应用。© 2023. 作者（们）。

A circular RNA (circRNA) is a non-coding RNA (ncRNA) derived from reverse splicing from pre-mRNA and is characterized by the absence of a cap structure at the 5' end and a poly-adenylated tail at the 3' end. Owing to the development of RNA sequencing and bioinformatics approaches in recent years, the important clinical value of circRNAs has been increasingly revealed. Circ_0067934 is an RNA molecule of 170 nucleotides located on chromosome 3q26.2. Circ_0067934 is formed via the reverse splicing of exons 15 and 16 in PRKCI (protein kinase C Iota). Recent studies revealed the upregulation or downregulation of circ_0067934 in various tumors. The expression of circ_0067934 was found to be correlated with tumor size, TNM stage, and poor prognosis. Based on experiments with cancer cells, circ_0067934 promotes cancer cell proliferation, migratory activity, and invasion when overexpressed or downregulated. The potential mechanism involves the binding of circ_0067934 to microRNAs (miRNAs; miR-545, miR-1304, miR-1301-3p, miR-1182, miR-7, and miR-1324) to regulate the post-transcriptional expression of genes. Other mechanisms include inhibition of the Wnt/β-catenin and PI3K/AKT signaling pathways. Here, we summarized the biological functions and possible mechanisms of circ_0067934 in different tumors to enable further exploration of its translational applications in clinical diagnosis, therapy, and prognostic assessments.© 2023. The Author(s).