评估代理报告的反应作为预测B-淋巴母细胞白血病儿童的运动和感觉性外周神经病变的指标。
Assessment of proxy-reported responses as predictors of motor and sensory peripheral neuropathy in children with B-lymphoblastic leukemia.
发表日期：2023 Aug 17
作者：
Rozalyn L Rodwin, Natalie J DelRocco, Emily Hibbitts, Meenakshi Devidas, Moira K Whitley, Caroline E Mohrmann, Reuven J Schore, Elizabeth Raetz, Naomi J Winick, Stephen P Hunger, Mignon L Loh, Marilyn J Hockenberry, Xiaomei Ma, Anne L Angiolillo, Kirsten K Ness, John A Kairalla, Nina S Kadan-Lottick
来源：
Disease Models & Mechanisms
摘要：
化疗引起的周围神经病变（CIPN）是儿童急性淋巴细胞白血病中常见的疾病，其诊断十分具有挑战性。本研究通过利用Children's Oncology Group AALL0932物理功能研究的数据，旨在确定通过儿童病患者结果数据收集工具所获得的家长/监护人代理报告反应是否能够识别出通过物理治疗师/职业治疗师（PT/OT）诊断的运动或感觉CIPN的儿童。四个变量在识别有无运动CIPN的儿童方面有中等的判别能力（c-指数0.76，95%置信区间[CI]: 0.64-0.84），但感觉和修正乐观模型的判别能力较弱（感觉模型c-指数0.65，95% CI：0.54-0.74）。需要新的代理报告评估工具来识别由PT/OT诊断的儿童CIPN。© 2023 Wiley Periodicals LLC.
Chemotherapy-induced peripheral neuropathy (CIPN), a common condition in children with acute lymphoblastic leukemia, can be challenging to diagnose. Using data from Children's Oncology Group AALL0932 physical function study, we sought to determine if parent/guardian proxy-reported responses from the Pediatric Outcomes Data Collection Instrument could identify children with motor or sensory CIPN diagnosed by physical/occupational therapists (PT/OT). Four variables moderately discriminated between children with and without motor CIPN (c-index 0.76, 95% confidence interval [CI]: 0.64-0.84), but sensory and optimism-corrected models had weak discrimination (c-index sensory models 0.65, 95% CI: 0.54-0.74). New proxy-report measures are needed to identify children with PT/OT diagnosed CIPN.© 2023 Wiley Periodicals LLC.