化疗药物常常导致胃肠道毒性，尤其是腹泻，影响患者的生活质量。随着一种潜在解决方案，作为化疗引起的腹泻的治疗方法，综合与替代医学（CAM）日益受到关注。为了总结当前关注草药作为辅助疗法，用于预防或治疗化疗引起的腹泻的研究，包括临床评估，作用机制，活性成分和草药与化疗药物之间的潜在药动学相互作用，我们在PubMed，CNKI，Google Scholar，Web of Science和Scopus上进行文献回顾，使用"Chemotherapy"，"Diarrhea"和"Complementary and Alternative Medicine"作为检索关键词。使用草药作为辅助剂能够有效治疗或预防CID，并能够改善或不影响化疗药物的抗肿瘤活性。在这些草药配方中，黄芩、生姜和人参是处方中最常用的草药。草药中的主要抗腹泻成分有黄芩苷、黄芩素、乙酰黄芩素、槲皮素、姜酚和人参皂苷。这些草药、配方和活性成分通过不同的机制来缓解CID，包括直接降低局部药物暴露量、抗炎作用、抑制上皮细胞凋亡或促进上皮干细胞再生。草药作为辅助疗法在多个临床试验中显示了预防或治疗CID的疗效。然而，需要更多设计良好的临床研究来进一步验证结果。尽管一些临床研究表明某些草药可能有助于减轻CID并提高疗效，但仍有必要评估草药的安全性。草药与药物之间的相互作用也是一个潜在的问题，但是很少有临床试验专门研究这个方面。在临床实践中，草药作为辅助治疗化疗引起的胃肠道毒性，特别是腹泻，显示出潜在的潜力。需要进一步设计良好的临床研究来验证它们的疗效，确保安全，并探索潜在的药物与草药之间的相互作用。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至epub@benthamscience.net。

Chemotherapeutic drugs used in cancer treatment often result in gastrointestinal toxicity, notably diarrhea, impacting patients' quality of life. Complementary and Alternative Medicine (CAM) has garnered increasing interest as an alternative to conventional approaches as a potential solution for managing chemotherapy-induced diarrhea (CID).To summarize current research focusing on herbal medicines as adjuvant therapy to prevent or treat chemotherapy-induced diarrhea, including clinical assessments, mechanism of actions, active components, and potential pharmacokinetic interactions between herbal medicines and chemotherapeutic drugs.We performed the literature review from PubMed, CNKI, Google Scholar, Web of Science, and Scopus using "Chemotherapy", "Diarrhea," and "Complementary and Alternative Medicine" as the search keywords.Using herbal medicines as adjuvants provides an effective approach to treating or preventing CID with improved or unaffected antitumor activity of chemotherapeutic drugs. Among these herbal formulations, scutellaria, ginger, and ginseng are the most frequently used herbs in the prescriptions for CID. The main antidiarrheal components in herbs are wogonin, baicalin, chrysin, quercetin, gingerol, and ginsenosides. These herbs, formulations, and bioactive components relieved CID through different mechanisms, including directly decreasing local drug exposure, anti-inflammation, inhibiting epithelial apoptosis, or promoting epithelium stem cell regeneration. The application of herbal medicines as adjunctive therapies showed efficacy in preventing or treating CID in multiple clinical trials. However, more well-designed clinical studies are expected to validate the results further. Despite some clinical studies demonstrating that certain herbal medicines could potentially attenuate CID and improve efficacy, it remains necessary to evaluate herbal safety. The interactions between herbs and drugs are also potential concerns, but few clinical trials have focused on investigating this aspect.In clinical practise, herbal medications show potential as adjuvant treatments for gastrointestinal toxicities brought on by chemotherapy, particularly diarrhoea. Further well-designed clinical studies are needed to validate their efficacy, ensure safety, and explore potential drug-herb interactions.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.