本研究基于手术方式,开发并验证了两个在线动态诺模图,针对非远处转移的皮肤黑色素瘤患者进行应用。
Development and validation of two online dynamic nomograms for patients with non-distant metastatic cutaneous melanoma based on surgical approaches.
发表日期:2023 Aug 18
作者:
Shiqi Wang, Yuedong Chen, Jiawei Sun, Ran Mo, Qian Tan
来源:
Burns & Trauma
摘要:
手术是非远处转移的皮肤黑素瘤(NMCM)的重要治疗方法。我们旨在基于手术方法和NMCM患者的临床病理特征构建和验证预后正态图。从2004年至2015年,我们从监测、流行病学和结果(SEER)数据库中获取了被诊断为皮肤黑素瘤的患者的数据。我们构建了两个在线正态图,用于根据手术方法预测NMCM患者的3年和5年黑素瘤特异性存活(MSS)。通过动态Harrell's一致指数(C-index)、决策曲线分析和临床影响曲线评估了这些正态图。进行了内部和外部数据验证。本研究纳入了14,091例NMCM病例。切除术组和切断组的正态图C-index分别为0.818和0.806,而在我们医院数据验证中分别为0.763和0.731。经过内部和自举验证,我们的两个正态图表现出良好的准确性和实用性。NMCM患者的存活率与切除边缘大小无关,而需要切断的患者存活率较差。我们生成了两个在线正态图,根据临床病理特征预测NMCM患者的生存情况,区别于手术方法。© 2023 The Authors. Cancer Medicine由约翰威利和儿子有限公司出版。
Surgery is an essential treatment for non-distant metastatic cutaneous melanoma (NMCM). We aim to construct and validate prognostic nomograms based on surgical approaches and the clinicopathological characteristics of NMCM patients.Data of patients diagnosed with cutaneous melanoma from 2004 to 2015 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Two online nomograms were constructed to predict the 3, 5-year melanoma-specific survival (MSS) for NMCM patients based on the surgical approaches. These nomograms were evaluated by the dynamic Harrell's concordance index (C-index), decision curve analysis and clinical impact curve. Both internal and external data verification were conducted.A total of 14,091 NMCM cases were included in this study. The C-index of the nomograms for the excisional surgery group and amputation group were 0.818 and 0.806, respectively, and 0.763 and 0.731, respectively, in our hospital data validation. After internal and bootstrap verification, our two nomograms showed good accuracy and practicality.NMCM patients exhibited equal survival rates independent of resection margin size, while those who needed amputation had worse survival rates. We generated two online nomograms distinguished by surgical approach to predict NMCM patient survival based on clinicopathological characteristics.© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.