研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

功能材料基于纳米制剂在慢性炎症相关疾病的预防、诊断和治疗方面的应用。

The applications of functional materials-based nano-formulations in the prevention, diagnosis and treatment of chronic inflammation-related diseases.

发表日期:2023
作者: Jingjing Wang, Rui Ni, Tingting Jiang, Dan Peng, Yue Ming, Hongjuan Cui, Yao Liu
来源: Frontiers in Pharmacology

摘要:

慢性炎症通常指由环境或生活方式导致的系统性免疫异常,它是各种皮肤病、自身免疫疾病、心血管疾病、肝脏疾病、消化系统疾病、癌症等的基础。治疗策略主要集中在免疫抑制和抗炎治疗上,但传统方法在增强药物实质治疗效果方面效果不佳。纳米材料因其高度灵活性、耐久性和简便的制备方法以及高盈利性而持续受到关注。纳米技术应用于临床医学的各个领域,如医学诊断、监测和治疗。然而,纳米材料本身引起的多种细胞毒性和加重炎症等相关问题不能忽视。本文综述了用于慢性炎症相关疾病的预防、诊断和治疗的功能性纳米材料配方,并旨在为现有治疗方法的增强和优化提供一些参考。版权©2023年 王、倪、姜、彭、明、崔和刘。
Chronic inflammation, in general, refers to systemic immune abnormalities most often caused by the environment or lifestyle, which is the basis for various skin diseases, autoimmune diseases, cardiovascular diseases, liver diseases, digestive diseases, cancer, and so on. Therapeutic strategies have focused on immunosuppression and anti-inflammation, but conventional approaches have been poor in enhancing the substantive therapeutic effect of drugs. Nanomaterials continue to attract attention for their high flexibility, durability and simplicity of preparation, as well as high profitability. Nanotechnology is used in various areas of clinical medicine, such as medical diagnosis, monitoring and treatment. However, some related problems cannot be ignored, including various cytotoxic and worsening inflammation caused by the nanomaterials themselves. This paper provides an overview of functional nanomaterial formulations for the prevention, diagnosis and treatment of chronic inflammation-related diseases, with the intention of providing some reference for the enhancement and optimization of existing therapeutic approaches.Copyright © 2023 Wang, Ni, Jiang, Peng, Ming, Cui and Liu.