糖尿病周围神经病变（DPN）是糖尿病患者残疾的主要原因，但目前可用药物的疗效较差。灸法是一种辅助治疗DPN的方法，可以减轻症状。10.6 μm激光灸疗法的远红外波长峰值与传统灸法的红外辐射光谱相近。其效果类似于灸法，并且不会引起疼痛、感染或产生刺激性烟雾。将二十四只雄性SD大鼠分为对照组（Con）、DPN组、激光灸组（LM）和二硫代氨基甲酸钠（PDTC）组（每组n=6）。DPN、LM和PDTC组的大鼠腹腔内注射1%链脲佐菌素（STZ）诱发DPN模型。LM组的大鼠在双侧ST36穴位上照射激光，每隔一天进行15分钟，连续进行14天。PDTC组的大鼠每天腹腔内注射一次PDTC。测量体重、血糖和爪部退缩机械阈值（PWMT），进行激光散斑成像（LSI）在造模前后和干预后1和2周。在干预后两周，分析血清白细胞介素1β（IL1β）、白细胞介素6（IL6）、肿瘤坏死因子α（TNFα）和神经生长因子（NGF）的变化，并观察坐骨神经中NF-κB和IκB-α蛋白的丰度以及NF-κB和IκB-α mRNA的水平。结果显示，10.6 μm激光灸疗法可以缓解DPN大鼠的疼痛、改善微循环并减轻炎症，可能通过NF-κB炎症途径起作用。©2023 Yin、Wang、Zhao、Lin和Shen版权所有。

Diabetic peripheral neuropathy (DPN) is the main cause of disability in diabetes patients but the efficacy of available drugs is poor. Moxibustion is an adjunctive treatment for DPN that can reduce symptoms. The peak value of the far infrared wavelength of 10.6 μm laser moxibustion is close to the infrared radiation spectrum of traditional moxibustion. Its effect is similar to that of moxibustion and does not cause pain, infection or produce irritating smoke. Twenty-four male SD rats were divided into control (Con), DPN, laser moxibustion (LM), and pyrrolidine dithiocarbamate (PDTC) groups (n=6/group). The DPN, LM and PDTC group rats were intraperitoneally injected with 1% streptozotocin (STZ) to induce a model of DPN. LM group rats were irradiated with a laser at bilateral ST36 acupoints for 15 min, once every other day, for 14 days. PDTC group rats were intraperitoneally injected with PDTC once a day. Body weight, blood glucose, and paw withdrawal mechanical threshold (PWMT) were measured and laser speckle imaging (LSI) performed before and after modeling and at 1 and 2 weeks after intervention. Two weeks after intervention, changes in serum interleukin 1β (IL1β), interleukin 6 (IL6), tumor necrosis factor α (TNFα) and nerve growth factor (NGF) were analyzed, and the abundance of NF-κB and IκB-α proteins and levels of NF-κB and IκB-α mRNAs in the sciatic nerve were observed. The results showed that 10.6 μm laser moxibustion can relieve pain, improve microcirculation, and alleviate inflammation in DPN rats, possibly via the NF-κB inflammatory pathway.Copyright © 2023 Yin, Wang, Zhao, Lin and Shen.