化学动力学疗法（Chemodynamic therapy，CDT）是一种新兴的癌症治疗策略，然而其治疗效果低和潜在副作用仍然限制了其应用。在本研究中，我们报告了一种半导电聚合物纳米催化剂（PGFe），它可以只在近红外（NIR）光激活时产生活性氧（ROS），以实现光动力疗法（PDT）协同CDT。该PGFe由半导电聚合物作为光敏剂、铁氧化物（Fe3O4）纳米颗粒作为CDT剂和葡萄糖氧化酶（GOx）组成，它们都被装载到一个单线态氧（1O2）响应性纳米载体中。在近红外激光照射下，PGFe通过光敏剂介导的PDT作用产生1O2，并且产生的1O2破坏1O2响应性纳米载体，从而控制释放Fe3O4纳米颗粒和GOx。在肿瘤微环境中，GOx催化葡萄糖降解形成过氧化氢（H2O2），从而大大改善Fe3O4纳米颗粒的CDT效果。因此，PGFe通过诱导细胞死亡获得了肿瘤细胞中放大的ROS水平。PGFe可用于治疗皮下4T1肿瘤，明显抑制肿瘤生长并抑制肺和肝转移。本研究为精确有效的肿瘤治疗提供了一种近红外光激活的ROS生成策略。

Chemodynamic therapy (CDT) is an emerging treatment strategy for cancer, but the low therapeutic efficacy and potential side effects still limit its applications. In this study, we report a semiconducting polymer nanocatalyst (PGFe) that can generate reactive oxygen species (ROS) only upon near-infrared (NIR) light-activation for photodynamic therapy (PDT)-synergized CDT. Such PGFe consists of a semiconducting polymer as a photosensitizer, iron oxide (Fe3O4) nanoparticles as CDT agents, and glucose oxidase (GOx), all of which are loaded into a singlet oxygen (1O2)-responsive nanocarrier. Under NIR laser irradiation, PGFe produces 1O2 through a photosensitizer-mediated PDT effect, and the produced 1O2 destroys the 1O2-responsive nanocarriers, leading to controlled releases of Fe3O4 nanoparticles and GOx. In a tumor microenvironment, GOx catalyzes glucose degradation to form hydrogen peroxide (H2O2), and thus the CDT effect of Fe3O4 nanoparticles is greatly improved. As such, an amplified ROS level in tumor cells is obtained by PGFe to induce cell death. PGFe can be utilized to treat subcutaneous 4T1 tumors, observably inhibiting the tumor growth and suppressing lung and liver metastasis. This study thus provides a NIR light-activated ROS generation strategy for precise and effective treatments of tumors.