在西班牙很少发表输血传播的丙型肝炎病毒（HEV）病例。在此，我们描述了在阿斯图里亚斯（西班牙）的血液和组织社区中心进行的一项对输血传播的HEV病例进行的完整调查。一名患有慢性髓性白血病的女性患者于2019年3月接受了异基因骨髓移植，并在手术后不久出现了肝功能异常。在移植手术前3个月，该患者从30位不同供血者那里接受了血液成分。对这些捐赠的冷冻血浆样本进行了HEV-RNA的检测。其中一位经常供血的捐赠者在捐献全血时被确定为无症状HEV RNA阳性。调查发现，该供血者的血浆单位，最初用于精制工业，其病毒RNA浓度为1.9×10^4拷贝/毫升。在输血后的25天，首次检测到从该供血者那里接受红细胞浓缩液的指标患者的HEV RNA。从捐赠者和受血者分离出的HEV RNA均被确定为3f亚型。对经核黄素基病原体灭活技术（PRT）处理的血小板浓缩液（PC）的受血者未感染，无论是在输血前还是后，都无HEV IgM、IgG和HEV RNA的存在。这个病例研究表明，HEV通过红细胞输血传播给受血者，而接受核黄素/紫外线灭活处理的血小板浓缩液的患者没有出现感染症状。PRT处理与HEV的非传播之间的因果关系有待确定。 © 2023 The Authors. 由Wiley Periodicals LLC代表AABB出版的《输血》发表。

Few cases of transfusion-transmitted hepatitis E virus (HEV) have been published in Spain. Here, we describe a well-characterized lookback investigation of a transfusion-transmitted HEV case at the Community Centre for Blood and Tissues of Asturias (Spain).A female patient with chronic myeloid leukemia underwent an allogeneic bone marrow transplant in March 2019 and showed alterations in liver function shortly afterwards. This patient received blood components from 30 different donors in the 3 months before the transplant. Frozen plasma samples from these donations were investigated for the presence of HEV-RNA. One frequent donor was identified as asymptomatic HEV RNA-positive at the time of his whole blood donation. The investigation revealed that this donor's plasma unit, originally intended for the fractionation industry, had a viral RNA concentration of 1.9 × 104 copies/mL. HEV RNA was detected initially in the index patient who received the red cell concentrate from this donor 25 days after the transfusion. HEV RNA isolated from both donor and recipient were identified as subtype 3f. The recipient of platelet concentrate (PC), treated with a riboflavin-based pathogen reduction technology (PRT) was not infected, being negative for the presence of HEV IgM, IgG, and HEV RNA before and after the transfusion.This case study shows that HEV was transmitted through red cell transfusion to a recipient, while the patient who received riboflavin/UV light treated PC did not develop signs of infection. A causal relationship between PRT treatment of the PC and the non-transmission of HEV remains to be established.© 2023 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.