Apelin及其受体在多种组织中表达，并在维持心血管系统和体液稳态中发挥重要作用。此外，该系统与糖尿病、高血压、肥胖、癌症、糖尿病视网膜病等多种疾病的关联已得以确定。该系统被视为许多上述疾病的治疗目标。G蛋白偶联受体（GPCRs）具有与其自身和其他受体形成寡聚体和二聚体的能力。这些寡聚体的形成与受体的信号转导途径的变化有关。对这些受体的寡聚体和二聚体的研究可能会颠覆药理学的原则。Apelin受体（APJ）也是一种GPCR，并已显示具有形成二聚体和寡聚体的能力。本文讨论了该受体与其自身受体和其他受体的二聚体化和寡聚体化，以及信号转导途径。Copyright © Bentham Science Publishers；有关任何问题，请发送电子邮件至epub@benthamscience.net。

Apelin and its receptor are expressed in many tissues and play an important role in maintaining the homeostasis of the cardiovascular system and body fluids. Also, the association of this system with many diseases, such as diabetes, hypertension, obesity, cancer, diabetic retinopathy, etc., has been determined. This system is considered a therapeutic goal in many mentioned diseases. G protein-coupled receptors (GPCRs) have the ability to form oligomers and dimers with themselves and other receptors. The formation of these oligomers is associated with a change in the signaling pathways of the receptors. Research on the oligo and dimers of these receptors can revolutionize the principles of pharmacology. The apelin receptor (APJ) is also a GPCR and has been shown to have the ability to form dimers and oligomers. This article discusses the dimerization and oligomerization of this receptor with its own receptor and other receptors, as well as the signaling pathways.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.