非处方非甾体抗炎药（NSAIDs）增加黑人美国人心血管不良事件（ACEs）的风险，然而对这些药物使用方面的种族差异的研究仍未得到充分研究。本研究旨在确定非处方NSAIDs和高效粉末状NSAIDs（HPP-NSAID）的使用中的种族差异。本回顾性分析调查了北卡罗来纳结肠癌研究的风险参与者（定义为自报高血压、糖尿病、心脏病或吸烟史≥20年者），这是一项基于人群的病例对照研究。我们使用多变量逻辑回归模型评估种族与任何OTC NSAID使用、HPP-NSAID使用和这些产品的常规使用之间的独立关联。在1286名参与者中，585名（45%）报告为黑人，701名（55%）报告为非黑人。总体上，665名（52%）报告使用任何非处方NSAID，204名（16%）报告使用HPP-NSAID。与非黑人相比，黑人更有可能报告任何非处方NSAID使用（57%对比48%）和HPP-NSAID使用（22%对比11%）。在多变量分析中，黑人（相对于非黑人）种族与NSAID使用（OR 1.4，95% CI（1.1，1.8））和HPP-NSAID使用（OR 1.8，95% CI（1.3，2.5））的高风险独立相关。经控制疼痛和社会经济地位，黑人风险ACEs的个体比非黑人个体更有可能使用任何OTC NSAID和HPP-NSAID。有关这种增加使用的潜在机制，需要进一步研究。© 2023. W. Montague Cobb-NMA Health Institute.

Black Americans are disproportionately affected by adverse cardiovascular events (ACEs). Over-the-counter (OTC) non-steroidal anti-inflammatory drugs (NSAIDs) confer increased risk for ACEs, yet racial differences in the use of these products remain understudied. This study sought to determine racial differences in OTC NSAID and high-potency powdered NSAID (HPP-NSAID) use.This retrospective analysis examined participants at risk of ACEs (defined as those with self-reported hypertension, diabetes, heart disease, or smoking history ≥ 20 years) from the North Carolina Colon Cancer Study, a population-based case-control study. We used multivariable logistic regression models to assess the independent associations of race with any OTC NSAID use, HPP-NSAID use, and regular use of these products.Of the 1286 participants, 585 (45%) reported Black race and 701 (55%) reported non-Black race. Overall, 665 (52%) reported any OTC NSAID use and 204 (16%) reported HPP-NSAID use. Compared to non-Black individuals, Black individuals were more likely to report both any OTC NSAID use (57% versus 48%) and HPP-NSAID use (22% versus 11%). In multivariable analyses, Black (versus non-Black) race was independently associated with higher odds of both NSAID use (OR 1.4, 95% CI (1.1, 1.8)) and HPP-NSAID use (OR 1.8 (1.3, 2.5)).Black individuals at risk of ACEs had higher odds of any OTC NSAID and HPP-NSAID use than non-Black individuals, after controlling for pain and socio-economic status. Further research is necessary to identify potential mechanisms driving this increased use.© 2023. W. Montague Cobb-NMA Health Institute.