了解胃癌（GC）早期阶段的分子机制转变至关重要。我们采用综合生物信息学方法，寻找各种生物信号通路和分子特征以了解胃癌的病理生理学。为了促进可能生物标志物的发现，可以进行快速诊断，从而改善诊断和患者预后。通过蛋白质相互作用网络、功能差异表达基因（DEGs）和通路富集研究，我们研究了慢性萎缩性胃炎和GC患者的基因表达谱。共从慢性萎缩性胃炎和GC患者的活检样本的微阵列数据集中鉴定出17个DEGs，其中包括8个上调和9个下调的基因。根据KEGG分析（p > 0.05），这些DEGs主要富集在CDK调节DNA复制和有丝分裂M-M/G1期通路中。我们在蛋白质相互作用网络中发现了两个核心基因MCM7和CDC6，并扩展了与110个节点和2103个边的最大交互。通过使用GEPIA和Human Protein Atlas数据库的验证，我们发现MCM7在GC组织中上调。综合我们的研究显示，MCM7在慢性萎缩性胃炎和GC中的高表达，提示该蛋白可能作为早期检测GC的有希望的生物标志物。 © 2023. 科学研究与技术学会。

It is important to comprehend how the molecular mechanisms shift when gastric cancer in its early stages (GC). We employed integrative bioinformatics approaches to locate various biological signalling pathways and molecular fingerprints to comprehend the pathophysiology of the GC. To facilitate the discovery of their possible biomarkers, a rapid diagnostic may be made, which leads to an improved diagnosis and improves the patient's prognosis.Through protein-protein interaction networks, functional differentially expressed genes (DEGs), and pathway enrichment studies, we examined the gene expression profiles of individuals with chronic atrophic gastritis and GC.A total of 17 DEGs comprising 8 upregulated and 9 down-regulated genes were identified from the microarray dataset from biopsies with chronic atrophic gastritis and GC. These DEGs were primarily enriched for CDK regulation of DNA replication and mitotic M-M/G1 phase pathways, according to KEGG analysis (p > 0.05). We discovered two hub genes, MCM7 and CDC6, in the protein-protein interaction network we obtained for the 17 DEGs (expanded with increased maximum interaction with 110 nodes and 2103 edges). MCM7 was discovered to be up-regulated in GC tissues following confirmation using the GEPIA and Human Protein Atlas databases.The elevated expression of MCM7 in both chronic atrophic gastritis and GC, as shown by our comprehensive investigation, suggests that this protein may serve as a promising biomarker for the early detection of GC.© 2023. Academy of Scientific Research and Technology.