眶尖综合征是一种罕见且病死率高的临床疾病。肿瘤、内分泌和炎症因素常是其发生的原因。作者描述了一名53岁的中国男性，被诊断患有眶尖综合征，合并2型糖尿病和真菌感染。治疗包括鼻内窥镜眶尖减压术、抗感染和充分清创。术后除了不可避免的视神经损伤外，突眼和头痛症状有所改善，全身感染得到及时控制，无复发或严重并发症。眶尖综合征难以治疗，尽早活检病变组织、积极手术减压和抗真菌治疗似乎是提高生存率的有效方法。版权所有 © 2023 by Mutaz B. Habal, MD.

Orbital apex syndrome, a clinical disease that is uncommon and has a high fatality rate. Tumor, endocrine, and inflammatory variables are frequently responsible for its occurrence. The authors describe a 53-year-old Chinese man who was diagnosed with orbital apex syndrome and coupled type 2 diabetes mellitus and a fungus infestation. Treatment included nasal endoscopic orbital apical decompression, anti-infection, and adequate debridement. Except for inevitable optic nerve damage, postoperative proptosis and headache manifestations improved, and systemic infection was timely contained with no signs of recurrence or serious complications occurred. The orbital apex syndrome is difficult to treat, and soon as possible biopsy of the lesion, aggressive surgical decompression, and antifungal treatment seem to be effective ways to improve survival rates.Copyright © 2023 by Mutaz B. Habal, MD.