环状RNA的负面影响：基因组不稳定的新驱动因素。
The dark side of circular RNA, a new driver of genome instability.
发表日期：2023 Aug 17
作者：
Ajit Kumar Sharma, Anish Thomas
来源：
Cell Chemical Biology
摘要：
环状RNA（circRNAs）是一类共价闭合的RNA分子，其功能目前还大多未被表征。在《癌细胞》杂志七月号上，Conn等人1发现circRNA能够结合同源DNA位点，形成circRNA-DNA杂交（circR环），从而推动MLL/KMT2A的遗传重排，与最具侵袭性的急性白血病相关。版权所有 © 2023。Elsevier Ltd.出版。
Circular RNAs (circRNAs) are covalently closed RNA molecules whose functions are still largely uncharacterized. In the July issue of Cancer Cell, Conn et al.1 demonstrate that circRNA can bind cognate DNA loci, forming circRNA-DNA hybrids (circR loops), driving genetic rearrangements of MLL/KMT2A, which are associated with the most aggressive acute leukemias.Copyright © 2023. Published by Elsevier Ltd.