作为生物医学领域的科学家，你精通英语和简体中文。请将以下段落翻译成简练、规范的简体中文，符合学术论文语言模式，并保持原文陈述结构。 乳腺癌（BC）作为女性最常见的死因之一，一直被视为全球性的健康挑战之一。尽管在诊断和治疗方法方面取得了各种进展，但由于缺乏治疗反应，相当一部分BC患者预后不佳。因此，研究BC进展中涉及的分子机制可以改善这些患者的治疗和诊断策略。细胞因子和生长因子依赖的信号通路在BC进展中起到关键作用。除了细胞因子和生长因子外，长链非编码RNA（lncRNA）在调控这些信号通路中也起着重要作用。因此，在本综述中我们讨论了lncRNA在乳腺肿瘤细胞的PI3K/AKT、MAPK和TGF-β信号通路调控中的作用。研究表明，在BC中，lncRNA主要通过促进这些信号通路发挥致癌作用。本综述可以作为引入lncRNA抑制作为可能的治疗策略，通过抑制BC患者的PI3K/AKT、MAPK和TGF-β信号通路来减少肿瘤生长的有效步骤。此外，考虑到lncRNA在大多数乳腺肿瘤中具有致癌作用和表达水平升高，lncRNA也可以被视为BC患者可靠的诊断标志物。© 2023. BioMed Central Ltd., part of Springer Nature.

Breast cancer (BC) as one of the most common causes of human deaths among women, is always considered one of the global health challenges. Despite various advances in diagnostic and therapeutic methods, a significant percentage of BC patients have a poor prognosis due to the lack of therapeutic response. Therefore, investigating the molecular mechanisms involved in BC progression can improve the therapeutic and diagnostic strategies in these patients. Cytokine and growth factor-dependent signaling pathways play a key role during BC progression. In addition to cytokines and growth factors, long non-coding RNAs (lncRNAs) have also important roles in regulation of such signaling pathways. Therefore, in the present review we discussed the role of lncRNAs in regulation of PI3K/AKT, MAPK, and TGF-β signaling pathways in breast tumor cells. It has been shown that lncRNAs mainly have an oncogenic role through the promotion of these signaling pathways in BC. This review can be an effective step in introducing the lncRNAs inhibition as a probable therapeutic strategy to reduce tumor growth by suppression of PI3K/AKT, MAPK, and TGF-β signaling pathways in BC patients. In addition, considering the oncogenic role and increased levels of lncRNAs expressions in majority of the breast tumors, lncRNAs can be also considered as the reliable diagnostic markers in BC patients.© 2023. BioMed Central Ltd., part of Springer Nature.