辅助语言区域，包括预供应运动区（pre-SMA），背外侧前额皮层（DLPFC）和视觉词形区（VWFA），在语言中起着重要的作用，但在静息态（rs）-fMRI领域中没有得到充分评估。本研究旨在确定使用种子相关（SBC）rs-fMRI定位辅助语言区域和对侧语言区域的发生率。我们回顾性地审查了40个rs-fMRI，以确定功能连接性（FC）与辅助语言区域的关系，其中在左半球的Broca区或Wernicke区附近与肿瘤成功生成的FC使用SBC分析。采用逻辑回归进行统计分析。在这40名患者中，使用位于与肿瘤同侧的左Broca区或左Wernicke区的种子进行SBC rs-fMRI。72.5%的病例显示与左DLPFC的FC，67.5%的病例显示与左pre-SMA的FC，并且52.5%的病例显示与右Broca区的FC。除其他相关性外，在从左Broca区和左Wernicke区播种时，我们发现年龄较大的患者对右Wernicke区的FC发生率较低（p值=0.016，odds ratio=0.94）。SBC rs-fMRI可以检测左半球辅助语言区域以及右半球主要和辅助语言区域。当从左Broca区和Wernicke区播种时，左DLPFC显示最高的FC发生率，其次是左pre-SMA。逻辑回归还显示，在某些情况下，FC至语言区域的发生率差异取决于年龄、种子位置和性别。

Secondary language areas, including the pre-supplementary motor area (pre-SMA), dorsolateral prefrontal cortex (DLPFC), and the visual word form area (VWFA) play important roles in speech, but have been under-evaluated in the realm of resting-state (rs)-fMRI. The purpose of this study is to determine the incidence that secondary language areas and contralateral language areas can be localized using seed-based correlation (SBC) rs-fMRI.We retrospectively reviewed 40 rs-fMRIs for functional connectivity (FC) to secondary language areas in cases where FC to Broca's or Wernicke's area near tumor in the left hemisphere were successfully generated using SBC analysis. Logistical regression was used for statistical analysis.SBC rs-fMRI with a seed in the left Broca's or Wernicke's area ipsilateral to the tumor was performed in the 40 patients. 72.5% of cases showed FC to the left DLPFC, 67.5% to left pre-SMA, and 52.5% of cases had FC to right Broca's area. In addition to other correlations, we found older patients have a lower incidence of FC to the right Wernicke's area when seeded from both left Broca's and left Wernicke's area (p-value = .016, odds ratio = 0.94).SBC rs-fMRI can detect left hemispheric secondary language areas as well as right hemispheric primary and secondary language areas. The left DLPFC showed the highest incidence of FC, followed by the left pre-SMA when seeded from both left Broca's and Wernicke's area. Logistics regression also showed in some instances, differences in the incidence of FC to language areas was dependent on age, seed location, and gender.