人类外周血T淋巴细胞基于T细胞受体（TCR）的差异被分为α-β T（αβT）细胞和γ-δ T（γδT）细胞。αβT细胞对于获得性免疫反应至关重要，而γδT细胞，虽然仅是一个小的亚群，却能识别抗原物质。这些抗原物质无需经过加工和呈递，并且不受MHC的限制。这使得γδT细胞与αβT细胞区分开来，并突显了它们在先天免疫中的独特作用。尽管数量较少，γδT细胞在抗肿瘤、抗感染和免疫调节方面具有重要意义。胶质母细胞瘤（GBM）是中枢神经系统中最常见的恶性肿瘤之一。单纯的手术切除对于治愈这种癌症是无效的。即使通过手术切除、放疗和化疗的组合，一些胶质母细胞瘤患者的预后仍然较差，并且复发率较高。本研究回顾了γδT细胞的分类、生物学和免疫学功能以及其在抗胶质母细胞瘤研究中的进展。© 2023年，Springer科学+工商媒体有限公司。

Human peripheral blood T lymphocytes are classified into alpha-beta T (αβΤ) cells and gamma-delta T (γδΤ) cells based on the difference in T cell receptors (TCRs). αβT cells are crucial for the acquired immune response, while γδΤ cells, though only a small subset, can recognize antigenic substances. These antigens do not need to be processed and presented and are not restricted by MHC. This distinguishes γδΤ cells from αβT cells and highlights their distinct role in innate immunity. Despite their small number, γδΤ cells hold significant significance in anti-tumor, anti-infection and immune regulation. Glioblastoma (GBM) represents one of the most prevalent malignant tumors within the central nervous system (CNS). Surgical resection alone proves to be an ineffective method for curing this type of cancer. Even with the combination of surgical resection, radiotherapy, and chemotherapy, the prognosis of some individuals with glioblastoma is still poor, and the recurrence rate is high. In this research, the classification, biological, and immunological functions of γδT cells and their research progress in anti-glioblastoma were reviewed.© 2023. Springer Science+Business Media, LLC.