卵巢癌是妇科肿瘤中导致女性死亡的主要原因。热原性凋亡是近期发现的一个与炎症有关的程序性细胞死亡类型。然而，有关热原性凋亡相关长链非编码RNA (lncRNA) 在卵巢癌中的研究仍然有限。本研究鉴定了 29 个热原性凋亡相关基因，并筛选出了 72 个热原性凋亡相关的 lncRNA。进一步通过 Cox 回归和 Lasso 回归从这 72 个 lncRNA 中筛选出 2 个与生存相关的 lncRNA，以构建一个能够预测卵巢癌预后的标志，并在测试集上进行了进一步验证。我们采用两个基因标志的风险评分，低风险组的生存率高于高风险组。功能富集分析表明，两个风险组之间的差异表达基因(DEGs)与肿瘤免疫相关。本研究表明，热原性凋亡相关基因与肿瘤免疫密切相关，并可能成为卵巢癌治疗的潜在治疗因素。© 2023. Springer Science+Business Media, LLC.

Ovarian cancer is a leading cause of death in females with gynecologic cancers. Pyroptosis is a relatively new discovered programmed cell death that is believed to be associated with inflammation. However, studies on pyroptosis-related lncRNAs in ovarian cancer are limited. In this study, we identified 29 pyroptosis-related genes and screened out 72 pyroptosis-related lncRNAs. Furthermore, the 72 lncRNAs were eliminated to 2 survival-related lncRNAs using Cox regression and Lasso regression to build an ovarian cancer prognostic prediction signature and were further validated on the test set. We adopted a riskscore from the two-gene signature, and the survival in low-risk group was higher than the high-risk group. Functional enrichment analysis indicated that the differentially expressed genes (DEGs) between two risk groups were associated with tumor immunity. This study implies that pyroptosis-related genes are closely related to tumor immunity and could be potential therapeutic factors for ovarian cancer treatment.© 2023. Springer Science+Business Media, LLC.