尽管免疫治疗和分子靶向疗法在晚期肿瘤患者中取得了显著的临床成功，但化疗仍然是大多数肿瘤患者常用的治疗方法。化疗药物通过其独特的机制有效地抑制肿瘤细胞的增殖和存活。然而，在化疗压力下，肿瘤细胞往往会出现严重的固有性和获得性药物耐药性，限制了化疗的有效性，并导致治疗失败。越来越多的证据表明，脂质代谢的改变可能与肿瘤化疗耐药性的发展有关。因此，在本综述中，我们提供了脂肪酸代谢及其对化疗耐药机制的影响的全面概述。此外，我们还讨论了以脂肪酸代谢为靶点的治疗策略，以克服药物耐药性的潜力。 版权所有 ©2023 Elsevier B.V. 发表。

Despite the remarkable clinical success of immunotherapy and molecular targeted therapy in patients with advanced tumors, chemotherapy remains the most commonly used treatment for most tumor patients. Chemotherapy drugs effectively inhibit tumor cell proliferation and survival through their remarkable mechanisms. However, tumor cells often develop severe intrinsic and acquired chemoresistance under chemotherapy stress, limiting the effectiveness of chemotherapy and leading to treatment failure. Growing evidence suggests that alterations in lipid metabolism may be implicated in the development of chemoresistance in tumors. Therefore, in this review, we provide a comprehensive overview of fatty acid metabolism and its impact on chemoresistance mechanisms. Additionally, we discuss the potential of targeting fatty acid metabolism as a therapeutic strategy to overcome drug resistance.Copyright © 2023. Published by Elsevier B.V.