芳香族氢化碳受体（Aryl hydrocarbon receptor，AhR）是一种通过内源性配体和外源性化学物质激活的细胞质转录因子。一旦AhR被激活，它将定位到细胞核，与AhR核翻译因子（ARNT）二聚化，并结合到外源性反应元件（XRE）上，以促进基因转录，特别是细胞色素P450 CYP1A1的转录。AhR不仅介导环境化学物质的毒性效应，还具有许多假定的生理功能。AhR生物学的这种二分法可能与长链非编码RNA（long non-coding RNA，lncRNA）的相互调控有关。lncRNA被定义为长度超过200个核苷酸且不编码蛋白质的转录本，与细胞分化、细胞增殖和细胞凋亡等许多生理过程有关。lncRNA还与疾病发生机制有关，特别是癌症的发展。最近的研究发现，环境化学物质激活AhR会影响lncRNA的表达和功能。本文概述了不同配体激活的AhR信号传导途径，并突出了AhR激活在生物学和毒理学反应中的主要差异。我们还详述了lncRNA的功能，并提供了AhR对其调控的最新数据。最后，我们概述了AhR与lncRNA之间功能重叠可能是AhR既作为内源性功能调节器又作为环境化学物质毒理反应介质的一种方式。总体而言，仍然需要进行更多的研究来充分理解AhR与lncRNA之间的动态相互作用。版权所有 © 2023。由Elsevier Inc.发表。

The aryl hydrocarbon receptor (AhR) is a cytosolic transcription factor activated by endogenous ligands and xenobiotic chemicals. Once the AhR is activated, it translocates to the nucleus, dimerizes with the AhR nuclear translator (ARNT) and binds to xenobiotic response elements (XRE) to promote gene transcription, notably the cytochrome P450 CYP1A1. The AhR not only mediates the toxic effects of environmental chemicals, but also has numerous putative physiological functions. This dichotomy in AhR biology may be related to reciprocal regulation of long non-coding RNA (lncRNA). LncRNA are defined as transcript more than 200 nucleotides in length that do not encode a protein but are implicated in many physiological processes such as cell differentiation, cell proliferation, and apoptosis. lncRNA are also linked to disease pathogenesis, particularly the development of cancer. Recent studies have revealed that AhR activation by environmental chemicals affects the expression and function of lncRNA. In this article, we provide an overview of AhR signaling pathways activated by diverse ligands and highlight key differences in the putative biological versus toxicological response of AhR activation. We also detail the functions of lncRNA and provide current data on their regulation by the AhR. Finally, we outline how overlap in function between AhR and lncRNA may be one way in which AhR can be both a regulator of endogenous functions but also a mediator of toxicological responses to environmental chemicals. Overall, more research is still needed to fully understand the dynamic interplay between the AhR and lncRNA.Copyright © 2023. Published by Elsevier Inc.