幽门螺杆菌（Helicobacter pylori）是一种感染全球约半数人口的胃肠道病原微生物。H. pylori感染是目前已知最严重的胃癌（GC）危险因素，而GC则是全球致癌死亡的第二大原因。我们进行了一项系统综述和荟萃分析，以评估H. pylori感染个体中GC的全球患病率。我们在PubMed、Web of Science和Embase数据库中进行了系统搜索，涵盖了2011年1月1日至2021年4月20日期间发表的有关H. pylori感染个体中GC患病率的研究。使用Metaprop软件包计算了95%置信区间内的汇总患病率，并采用随机效应模型估计了汇总患病率。我们还使用I2指数进行了量化。根据Higgins分类方法，I2值高于0.7被确定为高异质性。在对17,438份报道进行了筛选后，我们评估了1053篇全文文章的资格；最终包括了来自32个国家的149篇研究数据。美洲（汇总患病率：18.06%，95% CI：16.48-19.63，I2：98.84%）和非洲（汇总患病率：9.52%，95% CI：5.92-13.12，I2：88.39%）具有最高和最低的患病率。在单个国家中，日本的H. pylori阳性患者中GC的汇总患病率最高（患病率：90.90%，95% CI：83.61-95.14），而瑞典的患病率最低（患病率：0.07%，95% CI：0.06-0.09）。在前瞻性病例系列中观察到最高和最低的患病率（汇总患病率：23.13%，95% CI：20.41-25.85，I2：97.70%）和回顾性队列（汇总患病率：1.17%，95% CI：0.55-1.78，I 2：0.10%）。这项系统综述和荟萃分析表明，H. pylori感染在不同地区的GC患者中存在差异。我们观察到在发达国家，大量GC患者与H. pylori相关。利用这些数据，可以采取地区性措施来预防和根除全球范围内的H. pylori感染，从而减少其并发症。© 2023. BioMed Central Ltd., part of Springer Nature.

Helicobacter pylori is a gastrointestinal pathogen that infects around half of the world's population. H. pylori infection is the most severe known risk factor for gastric cancer (GC), which is the second highest cause of cancer-related deaths globally. We conducted a systematic review and meta-analysis to assess the global prevalence of GC in H. pylori-infected individuals.We performed a systematic search of the PubMed, Web of Science, and Embase databases for studies of the prevalence of GC in H. pylori-infected individuals published from 1 January 2011 to 20 April 2021. Metaprop package were used to calculate the pooled prevalence with 95% confidence interval. Random-effects model was applied to estimate the pooled prevalence. We also quantified it with the I2 index. Based on the Higgins classification approach, I2 values above 0.7 were determined as high heterogeneity.Among 17,438 reports screened, we assessed 1053 full-text articles for eligibility; 149 were included in the final analysis, comprising data from 32 countries. The highest and lowest prevalence was observed in America (pooled prevalence: 18.06%; 95% CI: 16.48 - 19.63; I2: 98.84%) and Africa (pooled prevalence: 9.52%; 95% CI: 5.92 - 13.12; I2: 88.39%). Among individual countries, Japan had the highest pooled prevalence of GC in H. pylori positive patients (Prevalence: 90.90%:95% CI: 83.61-95.14), whereas Sweden had the lowest prevalence (Prevalence: 0.07%; 95% CI: 0.06-0.09). The highest and lowest prevalence was observed in prospective case series (pooled prevalence: 23.13%; 95% CI: 20.41 - 25.85; I2: 97.70%) and retrospective cohort (pooled prevalence: 1.17%; 95% CI: 0.55 - 1.78; I 2: 0.10%).H. pylori infection in GC patients varied between regions in this systematic review and meta-analysis. We observed that large amounts of GCs in developed countries are associated with H. pylori. Using these data, regional initiatives can be taken to prevent and eradicate H. pylori worldwide, thus reducing its complications.© 2023. BioMed Central Ltd., part of Springer Nature.