研究动态
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预防性使用Mepitel® Film预防癌症患者辐射引起的潮湿脱皮

Prophylactic Use of Mepitel® Film to Prevent Radiation-Induced Moist Desquamation in Cancer Patients.

发表日期:2023 Jul
作者: Nahla A Tayyib
来源: ANTIOXIDANTS & REDOX SIGNALING

摘要:

几十年来,癌症患者的治疗选择有限,仅限于手术、化疗和放疗,或者它们的联合治疗。然而,近年来通过干细胞疗法、激素疗法、抗血管生成治疗、免疫疗法、树突状细胞靶向治疗、消融疗法、纳米颗粒、天然抗氧化剂、辐射探测技术、化学动力疗法、声动力疗法和铁依赖性细胞死亡疗法的引入取得了显著的进展。放疗是一种利用高剂量辐射消灭癌细胞和缩小肿瘤的癌症治疗方法。这种治疗在作为一种原发治疗、辅助治疗或姑息治疗时都十分有效。它是一种必需的、高效的、经济实惠的干预措施,对于提供适当的姑息性肿瘤学护理至关重要。尽管诸如调强放疗等癌症治疗模式已经得到发展,但它们依然存在损害皮肤和周围健康组织的风险。放疗可导致临床毒性,从而导致慢性或急性放射性皮炎,具体取决于治疗引起的毒性。无论是慢性还是急性,放射性皮炎都可能导致皮肤脱落,从而形成创面。这种脱落还可能导致不愈合的溃疡和放射性坏死。Mepitel®膜有助于控制癌症患者放射性潮湿脱屑。关于Mepitel膜预防放射性潮湿脱屑的临床试验在不同国家的患者中并没有显示出相似性,然而,基于膜的方法比其他方法更有益。本综述研究了用于管理放射性皮炎的各种敷料类型,以提高创面愈合效果,同时避免对新生组织的损害。此外,本综述比较了使用Mepitel膜治疗放射性潮湿脱屑与其他方法的效果。版权所有 © 2023 Tayyib等人。
Cancer patients had limited treatment options for decades, such as surgery, chemotherapy, and radiation therapy, alone or combined. However, there have been substantial improvements in recent years with the introduction of stem cell therapy, hormone therapy, anti-angiogenic treatments, immunotherapy, dendritic cell-based targeted therapy, ablation therapy, nanoparticles, natural antioxidants, radionics, chemodynamic therapy, sonodynamic therapy, and ferroptosis-based therapy. Radiation therapy, or radiotherapy, is a cancer treatment that employs high doses of radiation to eliminate cancer cells and shrink tumors. This treatment is effective as a primary, adjuvant, or palliative therapy. It is an essential, efficient, cost-effective intervention crucial for providing proper palliative oncology care. Although cancer treatment modalities such as intensity-modulated radiotherapy have advanced, they still risk harming the skin and surrounding healthy tissue. Radiotherapy may induce clinical toxicity leading to chronic or acute radiation dermatitis, depending on the toxicity caused by the therapy. Radiation dermatitis, whether in its chronic or acute form, can cause skin shedding that may result in the formation of wounds. Such shedding can also lead to non-healing ulcers and radionecrosis. Mepitel® film helps control radiation-induced moist desquamation in cancer patients. Clinical trials on the prophylactic use of Mepitel film on radiation-induced moist desquamation did not show similarities among patients from various countries; however, the film-based method is more beneficial than other methods. This review examines the various types of dressings utilized in managing radiation-induced dermatitis to enhance wound healing effectiveness while avoiding harm to newly developing tissues. Additionally, this review compares the effectiveness of using Mepitel film for treating radiation-induced moist desquamation to other methods.Copyright © 2023, Tayyib et al.