急性淋巴细胞白血病（ALL）是一种血液病，其特征是造血系统功能障碍导致干细胞发育在特定阶段停滞，抑制细胞血液成分的平均产量。BCP-ALL是B细胞系列前体的肿瘤。BCP-ALL是由多种机制引起和维持的，这些机制使得该疾病具有肿瘤潜力以及遗传和细胞学特征。这些病理特征用于BCP-ALL的诊断和预后评估。然而，大多数这些辅助临床工具只能通过骨髓穿刺获得，而骨髓穿刺是一项侵入性研究，可能会延迟疾病的诊断和随访，此外还存在麻醉风险对于儿科患者来说。因此，寻找非侵入性和易于获取的方法来提供与诊断、预后和疾病监测相关的信息非常关键，例如循环生物标志物。在肿瘤学中，生物标志物是指任何可测量的指标，用于证明恶性、肿瘤行为、预后或治疗反应的存在。本综述总结了与BCP-ALL相关的循环分子，其具有潜在的诊断价值，在监测疾病特定临床特征方面有分类能力，并能够确定每个BCP-ALL阶段的演变和患者预后。同样地，我们提供并分类可能在进一步的临床研究或BCP-ALL的治疗靶点鉴定中使用的生物标志物。

Acute lymphoblastic leukemia (ALL) is a hematological disease characterized by the dysfunction of the hematopoietic system that leads to arrest at a specific stage of stem cells development, suppressing the average production of cellular hematologic components. BCP-ALL is a neoplasm of the B-cell lineage progenitor. BCP-ALL is caused and perpetuated by several mechanisms that provide the disease with its tumor potential and genetic and cytological characteristics. These pathological features are used for diagnosis and the prognostication of BCP-ALL. However, most of these paraclinical tools can only be obtained by bone marrow aspiration, which, as it is an invasive study, can delay the diagnosis and follow-up of the disease, in addition to the anesthetic risk it entails for pediatric patients. For this reason, it is crucial to find noninvasive and accessible ways to supply information concerning diagnosis, prognosis, and the monitoring of the disease, such as circulating biomarkers. In oncology, a biomarker is any measurable indicator that demonstrates the presence of malignancy, tumoral behavior, prognosis, or responses to treatments. This review summarizes circulating molecules associated with BCP-ALL with potential diagnostic value, classificatory capacity during monitoring specific clinic features of the disease, and/or capacity to identify each BCP-ALL stage regarding its evolution and outcome of the patients with BCP-ALL. In the same way, we provide and classify biomarkers that may be used in further studies focused on clinical approaches or therapeutic target identification for BCP-ALL.