人体中两个重要系统——凝血系统和免疫系统之间存在紧密联系，这些联系从根本上决定了患者的健康状况。这些系统通过几个共同的调节途径共同协作，其中包括组织因子(TF)通路。表达TF并产生促炎细胞因子的免疫细胞可以影响凝血，而凝血因子和过程则通过激活免疫细胞和控制其功能来相互影响免疫应答。这些共同通路有助于维持健康，并参与多种病理条件。由感染、炎症或组织损伤引发的失调凝血可能导致弥散性血管内凝血(DIC)等疾病。与此同时，免疫失调可能导致凝血障碍和血栓并发症。本综述阐明了这些复杂的相互作用，强调了它们在自身免疫性疾病和癌症发病机制中的作用。了解这些系统之间复杂的相互作用对于疾病管理和有效治疗的发展至关重要。通过探索这些共同的调节机制，我们可以发现针对这些复杂疾病的创新治疗策略。因此，本文全面概述了凝血系统和免疫系统之间相互作用的重要性，突出了其在健康维护和疾病发病机制中的意义。

The coagulation and immune systems, two vital systems in the human body, share intimate connections that fundamentally determine patient health. These systems work together through several common regulatory pathways, including the Tissue Factor (TF) Pathway. Immune cells expressing TF and producing pro-inflammatory cytokines can influence coagulation, while coagulation factors and processes reciprocally impact immune responses by activating immune cells and controlling their functions. These shared pathways contribute to maintaining health and are also involved in various pathological conditions. Dysregulated coagulation, triggered by infection, inflammation, or tissue damage, can result in conditions such as disseminated intravascular coagulation (DIC). Concurrently, immune dysregulation may lead to coagulation disorders and thrombotic complications. This review elucidates these intricate interactions, emphasizing their roles in the pathogenesis of autoimmune diseases and cancer. Understanding the complex interplay between these systems is critical for disease management and the development of effective treatments. By exploring these common regulatory mechanisms, we can uncover innovative therapeutic strategies targeting these intricate disorders. Thus, this paper presents a comprehensive overview of the mutual interaction between the coagulation and immune systems, highlighting its significance in health maintenance and disease pathology.