具有不同形状和特殊磁性和热性能的磁性纳米颗粒对于磁性温热疗法具有潜在应用前景。该疗法的效率主要取决于纳米颗粒的物理特性，包括类型、尺寸和形状。本文介绍了在外部时变磁场作用下注射立方/球形磁性纳米颗粒于同心组织结构（恶性和正常组织）内所诱导的温热温度数值。纳米颗粒在肿瘤（良性/恶性）组织内的空间-时间分布采用生物热传输方程（Pennes方程）进行模拟。在Comsol Multiphysics中，开发了一个包括空间-时间纳米颗粒传输和加热的复杂热流体模型。与球形纳米颗粒相比，立方形磁性纳米颗粒在肿瘤体积内提供了更大的治疗温度的空间分布。分析了诱导肿瘤区域较小体积的治疗（温热）温度（40 ÷ 45 °C）的纳米颗粒剂量。这些体积（受温热温度数值覆盖）的大小根据不同的立方体/球形磁性纳米颗粒剂量进行计算。与球形磁性纳米颗粒相比，立方形磁性纳米颗粒的低剂量在肿瘤区域内提供了更大范围的温热温度数值。纳米颗粒剂量以质量浓度与最大临床接受剂量之间的比值表示。该热流体分析是一种重要的计算工具，可用于计算在组织内产生治疗性温度数值的纳米颗粒剂量。

Magnetic nanoparticles (MNPs) with various shapes and special (magnetic and thermal) properties are promising for magnetic hyperthermia. The efficiency of this therapy depends mainly on the MNPs' physical characteristics: types, sizes and shapes. This paper presents the hyperthermic temperature values induced by cubic/sphere-shaped MNPs injected within a concentric tissue configuration (malignant and healthy tissues) when an external time-dependent magnetic field was applied. The space-time distribution of the nanoparticles as a result of their injection within a tumoral (benign/malign) tissue was simulated with the bioheat transport equation (Pennes equation). A complex thermo-fluid model that considers the space-time MNP transport and its heating was developed in Comsol Multiphysics. The cubic-shaped MNPs give a larger spatial distribution of the therapeutic temperature in the tumoral volume compared to the spherical-shaped ones. MNP doses that induce the therapeutic (hyperthermic) values of the temperature (40 ÷ 45 °C) in smaller volumes from the tumoral region were analyzed. The size of these regions (covered by the hyperthermic temperature values) was computed for different magnetite cubic/sphere-shaped MNP doses. Lower doses of the cubic-shaped MNPs give the hyperthermic values of the temperature in a larger volume from the tumoral region compared with the spheric-shaped MNPs. The MNP doses were expressed as a ratio between mass concentration and the maximum clinical accepted doses. This thermo-fluid analysis is an important computational instrument that allows the computations of the MNP doses that give therapeutic temperature values within tissues.