肺癌仍然是全球男性和女性患者中的一种主要恶性肿瘤，其中非小细胞肺癌（NSCLC）是最常见的类型之一。多种机制已被发现有利于肿瘤生长，并阻碍肺癌患者治疗方案的疗效。在调节肿瘤生长方面发挥关键作用的抑癌基因中，磷酸酯酶和张力蛋白同源物（PTEN）是重要的家族成员之一，参与调控肿瘤细胞的多种功能活动，包括细胞增殖、凋亡、血管生成和转移。值得注意的是，临床研究还证实了具有PTEN功能受损、突变或丧失的肺肿瘤与低生存率或高肿瘤复发率相关。因此，PTEN被探索作为一个有前景的抗癌靶点。重要的是，PTEN与多个信号通路的相互作用能为肺癌治疗提供新的方法。本综述强调了PTEN在治疗NSCLC中的重要性和其意义。

Lung cancer remains one of the major human malignancies affecting both men and women worldwide, with non-small cell lung cancer (NSCLC) being the most prevalent type. Multiple mechanisms have been identified that favor tumor growth as well as impede the efficacy of therapeutic regimens in lung cancer patients. Among tumor suppressor genes that play critical roles in regulating cancer growth, the phosphatase and tensin homolog (PTEN) constitutes one of the important family members implicated in controlling various functional activities of tumor cells, including cell proliferation, apoptosis, angiogenesis, and metastasis. Notably, clinical studies have also documented that lung tumors having an impaired, mutated, or loss of PTEN are associated with low survival or high tumor recurrence rates. To that end, PTEN has been explored as a promising target for anti-cancer agents. Importantly, the ability of PTEN to crosstalk with several signaling pathways provides new approaches to devise effective treatment options for lung cancer treatment. The current review highlights the significance of PTEN and its implications in therapeutic approaches against NSCLC.