体力活动（PA）可能减轻睾丸生殖细胞肿瘤（TGCT）长期幸存者外周心脏代谢毒性的影响。在这个横断面研究中，我们评估了经常进行PA对代谢综合征（MetS）患病率以及心脏代谢健康和慢性炎症指标的影响，针对长期TGCT幸存者人群进行了分析。通过评估长期TGCT幸存者（n=195，年龄=41.1±8.1岁，疗程后11.7±5.2年）和健康男性对照组（n=41，年龄=38.2±8.8岁）的MetS患病率，并使用Baecke的经常PA问卷评估经常PA的情况。根据中位数划分为低PA组和高PA组来进行差异性分析。并比较低PA组和高PA组（涵盖整个样本、疾病分期不同的TGCT幸存者亚样本和健康对照组之间的差异），以及TGCT幸存者和对照组之间的差异。然后，根据治疗后时间（5-15/15/30年）和化疗周期数（≤3/>3），将TGCT幸存者分为与年龄和BMI匹配的亚组，以便在给定的TGCT幸存者亚人群中检测经常PA对心脏代谢健康的年龄和BMI独立影响。我们生成了经常PA和运动活动与心脏代谢和炎症标志物的相关矩阵。TGCT幸存者的MetS患病率高于对照组。高经常PA得分的患者腰围和系统性炎症指数较低。经常PA得分与高密度脂蛋白胆固醇呈正相关，与腰围和动脉粥样硬化风险呈负相关。此外，经常PA的心脏代谢好处在疾病分期为1和2的患者中更为显著。根据化疗剂量和治疗后时间划分的患者亚人群的经常PA影响明确显示，更高水平的经常PA与较低的MetS成分数量相关，除了接受了超过3个化疗周期并在治疗后15年以上接受检查的患者外。更高水平的经常PA有效缓解了TGCT幸存者的心脏代谢毒性。具有更高累积剂量化疗的患者可能需要结构化的运动干预，包括更高强度的体力活动，以实现心脏代谢健康的显著改善。© 2023. 作者。

Physical activity (PA) may mitigate late cardiometabolic toxicity of cisplatin-based chemotherapy in testicular germ cell tumor (TGCT) long-term survivors. In this cross-sectional study, we evaluated the effects of habitual PA on metabolic syndrome (MetS) prevalence, and on the markers of cardiometabolic health and chronic inflammation in a population of long-term TGCT survivors.MetS prevalence was evaluated, and habitual PA was assessed using Baecke's habitual PA questionnaire in TGCT survivors (n=195, age=41.1±8.1years, 11.7±5.2years post-therapy) and healthy male controls (n=41, age=38.2±8.8years). Participants were stratified into low- and high-PA groups based on median values. Differences were examined between low- and high-PA groups (in the entire sample, TGCT survivor sub-samples differing in disease stage, and healthy controls), and between TGCT survivors and controls. Next, TGCT survivors were stratified into age- and BMI-matched sub-groups based on post-treatment time (5-15/15/30years) and number of chemotherapy cycles (≤3/>3), allowing us to detect age- and BMI-independent effects of habitual PA on cardiometabolic health in the given TGCT survivor sub-populations. A correlation matrix of habitual PA and sport activity with cardiometabolic and pro-inflammatory markers was generated.TGCT survivors had higher MetS prevalence than controls. Patients with high habitual PA had lower waist circumference and Systemic Inflammation Index. Habitual PA scores correlated positively with HDL-cholesterol and negatively with waist circumference and atherogenic risk. Furthermore, cardiometabolic benefits of habitual PA were more pronounced in patients with disease stages 1 and 2. Effects of habitual PA on patients sub-populations stratified by chemotherapy dose and post-treatment time clearly showed that higher levels of habitual PA were associated with lower numbers of MetS components, except for patients who received more than 3 chemotherapy cycles and were examined more than15 years post-therapy.Higher levels of habitual PA effectively mitigated cardiometabolic toxicity in TGCT survivors. Patients with higher cumulative doses of chemotherapy may need structured exercise interventions involving higher-intensity physical activity to achieve significant improvements in cardiometabolic health.© 2023. The Author(s).