完整梅氏结肠切除（CMER）能够改善右半结肠切除术的淋巴结清扫并遵循胚胎学层面。然而，其对无癌存活和总体生存率的影响存在质疑。因此，我们旨在通过对文献进行系统综述和可用证据的荟萃分析，确定该技术的潜在益处。我们于2023年2月22日在Web of Science、PubMed/Medline和Embase数据库进行检索。包括研究对象为成年患者，接受CMER作为原发性结肠癌治疗的右半结肠切除术的短期和长期肿瘤学结局的原始研究纳入考虑范围。采用随机效应模型提取并汇总结果数据。通过数据库检索共发现了586篇文章，并从引文检索中筛选出18篇。最终纳入24篇文章。荟萃分析显示，与标准右半结肠切除术相比，CMER能够提高淋巴结检出数量（5个研究，1479名患者，MD 9.62，95% CI 5.83-13.41，p>0.0001，I2 84%），提高5年总体生存率（5个研究，2381名患者，OR 1.88，95% CI 1.14-3.09，p=0.01，I2 66%），提高5年无病生存率（4个研究，1376名患者，OR 2.21，95% CI 1.51-3.23，p<0.0001，I2 0%），降低局部复发的发生率（4个研究，818名患者，OR 0.27，95% CI 0.09-0.79，p=0.02，I2 0%）。两种手术技术在围手术期并发症方面相似（8个研究，3899名患者，OR 1.04，95% CI 0.89-1.22，p=0.97，I2 0%）。观察性和随机研究的荟萃分析结果表明，对于原发性右半结肠癌，采用CMER进行右半结肠切除术能够改善肿瘤学结果，而不增加术后并发症/死亡率。需要有高质量的证据和对选定患者进行随机试验的确认，以评估谁可以从该手术中获益。©2023. 作者。

Complete mesocolic excision improves lymphadenectomy for right hemicolectomy and respects the embryological planes. However, its effect on cancer-free and overall survival is questioned. Therefore, we aimed to determine the potential benefits of the technique by performing a systematic review of the literature and meta-analysis of the available evidence.Web of Science, PubMed/Medline, and Embase were searched on February 22, 2023. Original studies on short- and long-term oncological outcomes of adult patients undergoing right hemicolectomy with complete mesocolic excision as a treatment for primary colon cancer were considered for inclusion. Outcomes were extracted and pooled using a model with random effects.A total of 586 publications were identified through database searching, and 18 from citation searching. Exclusion of 552 articles left 24 articles for inclusion. Meta-analysis showed that complete mesocolic excision increased the lymph node harvest (5 studies, 1479 patients, MD 9.62, 95% CI 5.83-13.41, p > 0.0001, I2 84%), 5-year overall survival (5 studies, 2381 patients, OR 1.88, 95% CI 1.14-3.09, p = 0.01, I2 66%), 5-year disease-free survival (4 studies, 1376 patients, OR 2.21, 95% CI 1.51-3.23, p < 0.0001, I2 0%) and decreased the incidence of local recurrence (4 studies, 818 patients, OR 0.27, 95% CI 0.09-0.79, p = 0.02, I2 0%) when compared to standard right hemicolectomy. Perioperative morbidity was similar between the techniques (8 studies, 3899 patients, OR 1.04, 95% CI 0.89-1.22, p = 0.97, I2 0%).Meta-analysis of observational and randomised studies showed that right hemicolectomy with complete mesocolic excision for primary right colon cancer improves oncologic results without increasing morbidity/mortality. These results need to be confirmed by high-quality evidence and randomised trials in selected patients to assess who may benefit from the procedure.© 2023. The Author(s).