作为细胞连接和支架蛋白，泛在且丰富表达的波美云在多种组织中参与了多种细胞活动，包括细胞黏附、迁移和信号传导等，对肿瘤发生发展具有重要作用。由于波美云在癌症中表达特异且定位差异明显，大多数研究人员关注波美云在癌症中的作用，它已成为很多人类癌症恶性特征的强有力驱动因素，为波美云作为早期诊断和靶向药物递送的生物标志物和治疗靶点的广泛应用提供了可能性。然而，目前对波美云相互作用分子和机制的系统综述仍然缺乏。在本文中，我们总结了波美云的结构、表达和功能，并主要关注了近期关于波美云与其相互作用分子的功能和物理相互作用的研究，为波美云在癌症治疗中的靶向潜力照亮了一线。© 2023. 作者授权Springer Science+Business Media, LLC, part of Springer Nature.

Plectin, as the cytolinker and scaffolding protein, are widely expressed and abundant in many tissues, and has involved in various cellular activities contributing to tumorigenesis, such as cell adhesion, migration, and signal transduction. Due to the specific expression and differential localization of plectin in cancer, most researchers focus on the role of plectin in cancer, and it has emerged as a potent driver of malignant hallmarks in many human cancers, which provides the possibility for plectin to be widely used as a biomarker and therapeutic target in the early diagnosis and targeted drug delivery of the disease. However, there is still a lack of systematic review on the interaction molecules and mechanism of plectin. Herein, we summarized the structure, expression and function of plectin, and mainly focused on recent studies on the functional and physical interactions between plectin and its interacting molecules, shedding light on the potential of targeting plectin for cancer therapy.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.