随着金属氧化物固有酶样活性的发现，纳米酶因其低成本、高稳定性、多酶活性和简便制备等特点引起了广泛关注。尤其在生物医学领域，纳米酶主要关注疾病检测、抗菌性能、抗肿瘤效果和炎症病症治疗。然而，纳米酶在再生医学中的应用潜力也引起了人们的兴趣，主要涉及创伤愈合、神经缺陷修复、骨再生和心血管疾病治疗等领域。本综述将纳米酶引入骨再生医学领域，将重点放在通过调节病理微环境促进骨软骨再生上。首先讨论了四种代表性纳米酶的催化机制。接着介绍了抑制骨软骨再生的病理微环境，以及纳米酶对骨软骨再生障碍的治疗机制总结。此外还包括了纳米酶在骨疾病治疗中的治疗潜力。为了提高纳米酶的治疗效率并促进其临床应用，本文还探讨了纳米酶在骨关节疾病方面的未来潜力，并讨论了一些重要挑战。本文受版权保护，版权所有。

With the discovery of the intrinsic enzyme-like activity of metal oxides, nanozymes have garnered significant attention due to their superior characteristics, such as low cost, high stability, multi-enzyme activity, and facile preparation. Notably, in the field of biomedicine, nanozymes primarily focus on disease detection, antibacterial properties, antitumor effects, and treatment of inflammatory conditions. However, the potential for application in regenerative medicine, which primarily addresses wound healing, nerve defect repair, bone regeneration, and cardiovascular disease treatment, is garnering interest as well. This review introduces nanozymes as an innovative strategy within the realm of bone regenerative medicine. The primary focus of this approach lies in the facilitation of osteochondral regeneration through the modulation of the pathological microenvironment. The catalytic mechanisms of four types of representative nanozymes are first discussed. The pathological microenvironment inhibiting osteochondral regeneration, followed by summarizing the therapy mechanism of nanozymes to osteochondral regeneration barriers are introduced. Furthermore, the therapeutic potential of nanozymes for bone diseases are included. To improve the therapeutic efficiency of nanozymes and facilitate their clinical translation, we also discuss future potential applications in osteochondral diseases and address some significant challenges. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.