鞘脂是所有真核细胞膜的必要组成部分。生物活性鞘脂分子——神经酰胺1-磷酸鞘脂（S1P）调节各种重要的生物学功能。本综述旨在全面解析S1P信号通路在不同病理条件下（包括细菌和病毒感染、自身免疫疾病、炎症和癌症）对各种免疫细胞功能的作用。我们在S1P信号通路在NOD/TLR通路、细菌和病毒感染、自身免疫疾病和肿瘤免疫学方面进行了论述。这意味着S1P信号通路的靶向治疗可以作为阻断这些病理的策略。我们对疾病中能量免疫系统起关键作用的靶向S1P信号通路的各个组分以及S1P信号通路抑制剂或调节剂的治疗目的的当前理解是本综述的主要焦点。版权所有 © 2023。Elsevier Ltd. 发行。

Sphingolipids are essential components of all eukaryotic membranes. The bioactive sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important biological functions. This review aims to provide a comprehensive overview of the role of S1P signaling pathway in various immune cell functions under different pathophysiological conditions including bacterial and viral infections, autoimmune disorders, inflammation, and cancer. We covered the aspects of S1P pathways in NOD/TLR pathways, bacterial and viral infections, autoimmune disorders, and tumor immunology. This implies that targeting S1P signaling can be used as a strategy to block these pathologies. Our current understanding of targeting various components of S1P signaling for therapeutic purposes and the present status of S1P pathway inhibitors or modulators in disease conditions where the host immune system plays a pivotal role is the primary focus of this review.Copyright © 2023. Published by Elsevier Ltd.