本文旨在研究进行根治性治疗的上颌骨黏膜鳞状细胞癌（MASCC）患者复发模式。回顾性收集了2006年2月至2020年5月期间进行MASCC根治性切除的41例患者的临床病理数据。研究结果包括局部、区域或远处复发作为治疗复发的第一部位。单变量分析确定了与复发类型相关的显著临床病理变量。多元回归分析生成预测模型。41例患者中有10例出现区域复发，9例在同侧颈淋巴结清扫术后表现为对侧复发。其中3例患者同侧颈部为pN0。区域复发的预测因素是淋巴结转移，尤其是伴有淋巴结外生长。多元分析中区域复发的结果确认淋巴结外生长是独立的预测因素。因此，MASCC患者中有淋巴结受累和淋巴结外生长的预测因素与对侧区域复发相关。因此，应将涉及腭部的MASCC颈部管理视为正中线疾病。版权所有，未经Elsevier Ltd授权，禁止使用。

The aim of this paper was to examine patterns of recurrence in patients undergoing curative treatment for maxillary alveolus squamous cell carcinoma (MASCC). Clinicopathological data on 41 patients undergoing curative resection for MASCC between February 2006 and May 2020 were retrospectively gathered. Outcomes included local, regional, or distant failure as first site of treatment recurrence. Univariate analysis identified significant clinicopathological variables for type of recurrence. Multivariate regression analysis generated predictive models. Ten of 41 patients developed regional recurrence, and nine manifested contralateral recurrence following ipsilateral neck dissection. In three patients the ipsilateral neck was pN0. Nodal metastasis was predictive of regional recurrence, particularly with extranodal tumour extension (ENE). Multivariate analysis with regional recurrence confirmed that ENE was independently predictive. Nodal disease and ENE in patients with MASCC was found to be predictive of contralateral regional recurrence. Management of the neck in MASCC that extends to the palatal aspect should therefore be considered as midline disease.Crown Copyright © 2023. Published by Elsevier Ltd. All rights reserved.