本研究调查了急性白血病中ICR，CD244以及其适配分子在CD8+T细胞中的角色。从21名急性淋巴细胞白血病（ALL）和6名急性髓系白血病（AML）患者以及20个对照组获得了血液样本。通过qRT-PCR评估了CD244，SAP，EAT-2和LncRNA-GSTT1-AS1的相对基因表达水平。ALL患者的CD8+T细胞中CD244，SAP和EAT-2的表达水平均显著低于对照组。有趣的是，SAP的表达水平比CD244低得多，表明SAP与CD244的比值较低。此外，AML患者的SAP表达水平也显著低于对照组。与对照组相比，ALL和AML患者的LncRNA-GSTT1-AS1表达没有显著差异。在ALL中CD8+T细胞中低SAP/CD244表达比率表明CD244在ALL中起到一种抑制作用。

This study investigated the role of the ICR, CD244, and its adapter molecules, in CD8+ T cells in acute leukemia.Blood samples were obtained from 21 ALL and 6 AML patients and 20 control subjects. Relative gene expression of CD244, SAP, EAT-2, and LncRNA-GSTT1-AS1 were evaluated using qRT-PCR.Expression of CD244, SAP, and EAT-2 were significantly lower in CD8+ T cells from ALL patients than those from control subjects. Interestingly, the expression of SAP was much lower than that of CD244, indicating a lower ratio of SAP to CD244. Also, SAP expression was significantly lower in AML patients compared to the control group. Expression of LncRNA-GSTT1-AS1 showed no significant difference in ALL and AML patients compared to control subjects.The low SAP/CD244 expression ratio in CD8+ T cells in ALL suggests an inhibitory role for CD244 in ALL.