高温局部腹腔化疗（HIPEC）已成为新辅助化疗后细胞减灭手术时的治疗选择。需要研究HIPEC的主动加热对术后疼痛的影响。本研究旨在探讨HIPEC是否能减轻术后疼痛。从KOV-HIPEC-01试验中筛选184例残余肿瘤尺寸<1 cm的晚期原发性卵巢癌患者，以1:1的比例随机分为HIPEC组和对照组。分析镇痛药物的使用和疼痛评分。细胞减灭手术后行高温局部腹腔化疗。主要目标是比较HIPEC组和对照组之间吗啡毫克当量和非阿片类药物的最大日剂量的消耗。次要目标是使用线性混合模型比较两组在数字评分尺度上的最低和最高疼痛强度。观察到非阿片类药物的消耗减少，术后第1和第2天最大日剂量更低。HIPEC组术后第1天的最大疼痛强度也较低。术后第7天的最低和最高疼痛强度没有明显差异。在术后早期阶段，将HIPEC添加到细胞减灭手术中并没有增加术后疼痛，这证实了镇痛药物使用减少和术后疼痛评分较低的结果。版权所有 © 2023 Elsevier Inc. 保留所有权利。

Hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a treatment option at the time of cytoreductive surgery after neoadjuvant chemotherapy. The effect of active warming of HIPEC on postoperative pain needs to be investigated. This study aimed to investigate whether HIPEC reduces postoperative pain.From the KOV-HIPEC-01 trial, a randomized controlled trial of HIPEC for advanced primary ovarian cancer, 184 patients with a residual tumor size <1 cm were randomly assigned to the HIPEC and control groups at a 1:1 ratio. The consumption of analgesics and pain scales were analyzed. Hyperthermic intraperitoneal chemotherapy was administered after cytoreductive surgery. The primary objective was to compare the consumption of opioids measured in morphine milligram equivalents and non-opioids measured as the maximum daily dose between the HIPEC and control groups. The secondary objective was to compare the minimum and maximum pain intensities on numeric rating scales between the two groups using a linear mixed model.Lesser consumption of non-opioids, with a lower mean maximum daily dose on postoperative days 1 and 2, was observed. The HIPEC group also experienced lower maximum pain intensities on postoperative day 1. No overall differences in the minimum or maximum pain intensities were observed on postoperative day 7.The addition of HIPEC to cytoreductive surgery did not lead to increased postoperative pain, as demonstrated by a reduction in the use of analgesics and lower scores on postoperative pain scales during the early postoperative period.Copyright © 2023 Elsevier Inc. All rights reserved.