Wnt信号传导系统是一个关键的途径，调节胚胎发育和成体稳态。分泌的过激相关蛋白(Secreted frizzled-related proteins, SFRPs)是Wnt信号传导的细胞外抑制剂，通过直接与Wnt配基或Frizzled受体结合发挥作用。SFRPs能作为抗Wnt剂，通过阻断Wnt配基的作用来抑制癌细胞生长。然而，在癌细胞中，SFRPs通常被启动子甲基化沉默，导致Wnt途径的超活化。表观遗传修饰剂可以逆转这种沉默并恢复SFRPs的表达。尽管SFRPs作为治疗靶点具有潜力，但SFRPs对肿瘤发展的影响仍不清楚。因此，有必要对不同癌症中SFRPs家族的不同成员的表达及其作为治疗靶点的潜力进行综述。本综述旨在总结当前关于肿瘤中SFRPs的知识，重点关注其表达模式和作为新型治疗靶点的潜力。版权 © 2023 作者。由Elsevier Masson SAS出版。保留所有权利。

The Wnt signaling system is a critical pathway that regulates embryonic development and adult homeostasis. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or Frizzled receptors. SFRPs can act as anti-Wnt agents and suppress cancer growth by blocking the action of Wnt ligands. However, SFRPs are often silenced by promoter methylation in cancer cells, resulting in hyperactivation of the Wnt pathway. Epigenetic modifiers can reverse this silencing and restore SFRPs expression. Despite the potential of SFRPs as a therapeutic target, the effects of SFRPs on tumor development remain unclear. Therefore, a review of the expression of various members of the SFRPs family in different cancers and their potential as therapeutic targets is warranted. This review aims to summarize the current knowledge of SFRPs in cancer, focusing on their expression patterns and their potential as novel therapeutic targets.Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.