及时识别和完全切除口腔鳞状细胞癌（OSCC）对有效治疗至关重要。然而，目前依赖于物理异常的诊断方法在临床环境中信息不足且不实用，导致口腔癌的晚期发现。此外，目前没有可靠的术中工具以实时评估手术边缘。荧光成像能够可视化癌症早期发生的生物过程，从而可以在早期阶段检测到小肿瘤。荧光成像可以有效辅助评估OSCC手术切除边缘，因其具有较高的灵敏度和空间分辨率。本综述以舌癌为OSCC的代表，并探讨了各种荧光技术在早期诊断和手术引导方面的应用。综述还讨论了这些技术在未来的潜在临床应用。版权©2023。Elsevier B.V.出版。

Timely identification and complete removal of oral squamous cell carcinoma (OSCC) through surgery is crucial for effective treatment. However, current diagnostic methods that rely on physical abnormalities are not very informative and practical in clinical settings, leading to the late detection of oral cancer. Furthermore, no dependable intraoperative tools available for assessing surgical margins in real-time. Fluorescence imaging allows the visualization of biological processes occurring in the early stages of cancer, and as a result, small tumors can be detected at an early stage. Fluorescence imaging can effectively aid in assessing excised edges during surgery for OSCC as it possesses high sensitivity and spatial resolution. This review focuses on tongue cancer as a representation of OSCC and delves into various fluorescence techniques that can aid in early diagnosis and surgical guidance. The review also discusses the potential clinical applications of these techniques in the future.Copyright © 2023. Published by Elsevier B.V.