量化分析化疗相关性心脏功能不全（CTRCD）的心脏磁共振成像（CMR）特征，并探讨它们对主要不良心血管事件（MACE）的预测价值。纳入了2015年1月至2021年1月期间间CMR受检的145名有癌症和心力衰竭的患者（男性：女性= 76：69，平均年龄= 63.0岁）。采用3T电磁共振扫描仪（西门子）进行CMR检查。比较了具有和不具有CTRCD的患者之间的两心室功能、本地T1 T2、细胞外体积分数（ECV）值和左心室（LV）晚期钆增强（LGE）。比较了中度到重度CTRCD患者和严重CTRCD患者之间的这些参数。采用Cox比例风险回归分析评估CTRCD患者随访期间CMR参数与MACE发生的关联。在145名患者中，61名患有CTRCD，84名患者没有CTRCD。CTRCD组的本地T1、ECV和T2（分别为1336.9毫秒、32.5%和44.7毫秒）明显高于非CTRCD组的数值（分别为1303.4毫秒、30.5%和42.0毫秒），差异具有统计学意义（P = 0.013、0.010和< 0.001）。在中度到重度CTRCD患者之间这些参数差异无统计学意义。CTRCD组的心室质量指数明显较小（65.0克/平方米对比78.9克/平方米；P < 0.001）。根据多变量Cox回归分析，T2（风险比[HR]：1.14，95%置信区间[CI]：1.01-1.27；P = 0.028）和定量LGE（HR：1.07，95%CI：1.01-1.13；P = 0.021）与CTRCD患者的MACE独立相关。CMR的定量参数有潜力评估CTRCD的心肌变化。CTRCD患者中即使在心脏功能严重不全发展之前，也表现出T2增加且LV质量降低。T2和定量LGE可能是CTRCD患者MACE的独立预测因素。版权所有© 2023年韩国放射学会。

To quantitatively analyze the cardiac magnetic resonance imaging (CMR) characteristics of chemotherapy-related cardiac dysfunction (CTRCD) and explore their prognostic value for major adverse cardiovascular events (MACE).A total of 145 patients (male:female = 76:69, mean age = 63.0 years) with cancer and heart failure who underwent CMR between January 2015 and January 2021 were included. CMR was performed using a 3T scanner (Siemens). Biventricular functions, native T1 T2, extracellular volume fraction (ECV) values, and late gadolinium enhancement (LGE) of the left ventricle (LV) were compared between those with and without CTRCD. These were compared between patients with mild-to-moderate CTRCD and those with severe CTRCD. Cox proportional hazard regression analysis was used to evaluate the association between the CMR parameters and MACE occurrence during follow-up in the CTRCD patients.Among 145 patients, 61 had CTRCD and 84 did not have CTRCD. Native T1, ECV, and T2 were significantly higher in the CTRCD group (1336.9 ms, 32.5%, and 44.7 ms, respectively) than those in the non-CTRCD group (1303.4 ms, 30.5%, and 42.0 ms, respectively; P = 0.013, 0.010, and < 0.001, respectively). They were not significantly different between patients with mild-to-moderate and severe CTRCD. Indexed LV mass was significantly smaller in the CTRCD group (65.0 g/m² vs. 78.9 g/m²; P < 0.001). According to the multivariable Cox regression analysis, T2 (hazard ratio [HR]: 1.14, 95% confidence interval [CI]: 1.01-1.27; P = 0.028) and quantified LGE (HR: 1.07, 95% CI: 1.01-1.13; P = 0.021) were independently associated with MACE in the CTRCD patients.Quantitative parameters from CMR have the potential to evaluate myocardial changes in CTRCD. Increased T2 with reduced LV mass was demonstrated in CTRCD patients even before the development of severe cardiac dysfunction. T2 and quantified LGE may be independent prognostic factors for MACE in patients with CTRCD.Copyright © 2023 The Korean Society of Radiology.