表观遗传调控在癌症发展和进展中起着关键作用。甲基化是一种重要的表观遗传修饰，通过向核酸和蛋白质中添加甲基基团来影响基因表达。铁过氧化脂质低氧死亡（ferroptosis）是一种由铁积累和脂质过氧化触发的新型调控性细胞死亡形式。最新证据表明，甲基化调控在癌症中在ferroptosis调控中起着重要作用。本综述旨在探讨癌症中ferroptosis的甲基化调控，包括活性氧化物和铁生物学活性、氨基酸和脂质代谢以及药物相互作用。本综述的研究发现可能为癌症的预防和治疗提供新的见解和策略。版权所有 © 2023. Elsevier B.V. 发布。

Epigenetic regulation plays a critical role in cancer development and progression. Methylation is an important epigenetic modification that influences gene expression by adding a methyl group to nucleic acids and proteins. Ferroptosis is a new form of regulated cell death triggered by the accumulation of iron and lipid peroxidation. Emerging evidence have shown that methylation regulation plays a significant role in the regulation of ferroptosis in cancer. This review aims to explore the methylation regulation of ferroptosis in cancer, including reactive oxygen species and iron bio-logical activity, amino acid and lipid metabolism, and drugs interaction. The findings of this review may provide new insights and strategies for the prevention and treatment of cancer.Copyright © 2023. Published by Elsevier B.V.