本文制备了一种用于表面增强拉曼散射（SERS）的杂化底物，它耦合了局域表面等离子共振（LSPR）、电荷转移（CT）共振和分子共振。剥离的二维TiS2纳米片具有半金属特性，能够加速与被测样品的CT反应，从而引发显著的化学机制增强。此外，凹型金阵列与薄的TiS2纳米片底部耦合，提供强烈的电磁增强效应。凹型金阵列是通过蚀刻较大的聚苯乙烯纳米球上组装的硅胶纳米球制备的，随后在其上沉积金层。通过改变金层厚度，可以调节金层附近的LSPR强度，以实现分子和CT共振的耦合，并最大化SERS增强效应。在涂覆了TiS2纳米片的等离子底物上，记录到了最佳的SERS性能，可以检测到若干甲基蓝浓度达到10-13  m，增强因子为2.1 × 109，这个浓度比TiS2纳米片（10-11  m）和等离子底物（10-9  m）的浓度低了几个数量级。本文介绍的三阶耦合共振的杂化底物在无标签的血清和尿液中对姜黄素（一种广泛应用于治疗多种癌症和炎症的药物）的监测中也展示了显著的优势。 © 2023 Wiley-VCH GmbH.

Herein, a hybrid substrate for surface-enhanced Raman scattering (SERS) is fabricated, which couples localized surface plasmon resonance (LSPR), charge transfer (CT) resonance, and molecular resonance. Exfoliated 2D TiS2 nanosheets with semimetallic properties accelerate the CT with the tested analytes, inducing a remarkable chemical mechanism enhancement. In addition, the LSPR effect is coupled with a concave gold array located underneath the thin TiS2 nanosheet, providing a strong electromagnetic enhancement. The concave gold array is prepared by etching silicone nanospheres assembled on larger polystyrene nanospheres, followed by depositing a gold layer. The LSPR intensity near the gold layer can be adjusted by changing the layer thickness to couple the molecular and CT resonances, in order to maximize the SERS enhancement. The best SERS performance is recorded on TiS2 -nanosheet-coated plasmonic substrates, with a detectable methylene blue concentration down to 10-13  m and an enhancement factor of 2.1 × 109 and this concentration is several orders of magnitude lower than that of the TiS2 nanosheet (10-11  m) and plasmonic substrates (10-9  m). The present hybrid substrate with triple-coupled resonance further shows significant advantages in the label-free monitoring of curcumin (a widely applied drug for treating multiple cancers and inflammations) in serum and urine.© 2023 Wiley-VCH GmbH.