全切除细胞减量手术（CRS）仍然是卵巢癌腹膜转移（PMOC）治疗的黄金标准。鉴于高PCI患者，先前腹部手术，炎症和纤维化变化的新辅助化疗率增加，尚未全面调查在CRS期间去除任何“类似腹膜疤痕组织”（PST）的益处。我们目标在这个回顾性队列研究中是确定PMOC患者中进行治愈性CRS ± HIPEC的PST中恶性细胞阳性的比例。这是一项回顾性研究，在我们的综合癌症中心进行，包括PMOC患者，进行治愈性CRS。在CRS期间，外科医生系统地切除或电烧良性外观的腹膜病变，不具有典型的硬结节、侵袭性和浸润性形态。我们的病理学家通过分析PST的存在来检测肿瘤细胞。研究了PST的存在和阳性以及不同患者变量之间的关系。51％的患者PST中存在恶性细胞。与阳性PST组相比，这些患者与低分化浆液肿瘤、高PCI（> 8）和较差的无病生存期（DFS）相关：阳性PST组为17个月，阴性PST组为29个月（p = 0.05），单变量分析显示。多变量分析表明，PCI > 8和低分化原发肿瘤组织学与DFS较差相关，而较高的PCI和FIGO进展较差与OS较差相关。良性外观的PST在51％的病例中存在恶性。应进一步在更大的队列中研究其系统切除的益处和预后价值。© 2023. BioMed Central Ltd., Springer Nature的一部分。

Complete cytoreductive surgery (CRS), remain the gold standard in the treatment of peritoneal metastases of ovarian cancer (PMOC). Given the increasing rate of neoadjuvant chemotherapy in patients with high PCI, prior abdominal surgeries, inflammation and fibrotic changes, the benefit of removing any "peritoneal scar-like tissues" (PST) during CRS, hasn't been thoroughly investigated. Our objective in this retrospective cohort was to identify the proportion of malignant cells positivity in PST of patients with PMOC, undergoing curative-intent CRS ± HIPEC.This is a retrospective study, conducted at our comprehensive cancer center, including patients with PMOC, presenting for curative-intent CRS. During CRS, benign-looking peritoneal lesions, lacking the typical hard nodular, aggressive, and invasive morphology, were systematically resected or electro fulgurated. PSTs were analyzed for the presence of tumoral cells by our pathologist. Correlations between the presence of PST and their positivity, and the different patients' variables, were studied.In 51% of patients, PST harbored malignant cells. Those were associated with poorly differentiated serous tumors, a high PCI (> 8) and a worse DFS: 17 months in the positive PST group versus 29 months in the negative PST group (p = 0.05), on univariate analysis. Multivariate analysis revealed that PCI > 8 and poorly differentiated primary tumor histology were correlated with a worse DFS, and that higher PCI and advanced FIGO were correlated with a worse OS.Benign-looking PST harbors malignancy in 51% of cases. The benefit of their systematic resection and their prognostic value should be further investigated in larger cohorts.© 2023. BioMed Central Ltd., part of Springer Nature.