分泌免疫球蛋白A (SIgA) 是粘膜中最丰富的免疫球蛋白亚型之一，在对抗入侵的病原体和抗原方面扮演着不可或缺的第一线保护作用。因此，呼吸道SIgA在呼吸粘膜免疫疾病中的作用越来越受到关注。虽然肠道粘膜免疫中SIgA的作用得到了广泛研究，但负责SIgA的细胞类型以及细胞间的相互作用仍不清楚。在这里，我们通过广泛搜索相关研究，并整理了SIgA与一些肺部疾病（COPD、哮喘、结核病、特发性肺纤维化、COVID-19、肺癌）之间的关系。发现SIgA参与了多种肺部疾病的发病机理和进展，旨在为相关肺部疾病的预防、诊断和治疗提供新思路。© 2023. BioMed Central Ltd., part of Springer Nature.

Secretory immunoglobulin A (SIgA) is one of the most abundant immunoglobulin subtypes among mucosa, which plays an indispensable role in the first-line protection against invading pathogens and antigens. Therefore, the role of respiratory SIgA in respiratory mucosal immune diseases has attracted more and more attention. Although the role of SIgA in intestinal mucosal immunity has been widely studied, the cell types responsible for SIgA and the interactions between cells are still unclear. Here, we conducted a wide search of relevant studies and sorted out the relationship between SIgA and some pulmonary diseases (COPD, asthma, tuberculosis, idiopathic pulmonary fibrosis, COVID-19, lung cancer), which found SIgA is involved in the pathogenesis and progression of various lung diseases, intending to provide new ideas for the prevention, diagnosis, and treatment of related lung diseases.© 2023. BioMed Central Ltd., part of Springer Nature.