最近，长非编码RNA由于在人类疾病中的异常表达而引起了广泛关注。LncMIR31HG是一种新型长非编码RNA，在多种疾病中存在异常表达，并与疾病进展的不同阶段有关。最近的研究表明，MIR31HG通过触发多种信号通路在人类疾病的发病机制中具有生物学功能，尤其是在癌症方面。更重要的是，MIR31HG的异常表达使其成为诊断和预后的潜在生物标志物，同时也是治疗的有希望的靶点。本综述旨在系统总结MIR31HG在人类疾病中的基因多态性、表达谱、生物学作用、潜在机制和临床应用。版权所有 © 2023 Ruan, Lei, Yuan, Li, Yang, Wang和Zhang。

Long non-coding RNAs have recently attracted considerable attention due to their aberrant expression in human diseases. LncMIR31HG is a novel lncRNA that is abnormally expressed in multiple diseases and implicated in various stages of disease progression. A large proportion of recent studies have indicated that MIR31HG has biological functions by triggering various signalling pathways in the pathogenesis of human diseases, especially cancers. More importantly, the abnormal expression of MIR31HG makes it a potential biomarker in diagnosis and prognosis, as well as a promising target for treatments. This review aims to systematically summarize the gene polymorphism, expression profiles, biological roles, underlying mechanisms, and clinical applications of MIR31HG in human diseases.Copyright © 2023 Ruan, Lei, Yuan, Li, Yang, Wang and Zhang.