中枢神经系统淋巴瘤是一种起源于中枢神经系统（脑、软脑膜、脊髓或眼睛）的非霍奇金恶性淋巴疾病，非常罕见且具有侵袭性。在过去的二十年里，无论是免疫受损还是免疫正常的患者，该病似乎有所增加。原发性大B细胞淋巴瘤累及小脑桥角（CPA）极为罕见：全球仅报道了15例CPA大B细胞淋巴瘤病例；根据我们的了解，还没有使用MR谱学研究这类病例。必须区分CPA大B细胞淋巴瘤与其他小脑桥角疾病，如听神经瘤和脑膜瘤。对于最佳处理，早期和准确的诊断非常重要，因为CPA大B细胞淋巴瘤对放疗和化疗敏感。在这里，我们报道了一例65岁男性左侧CPA累及B细胞淋巴瘤的罕见病例，该患者出现左侧听力丧失已有3个月，并通过MR和TC图像进行了说明。重点在于，由于其更高的特异性，MR谱学对于确诊原发性淋巴瘤并将其与听神经瘤或脑膜瘤区分开来至关重要。因此，在怀疑CPA的恶性异位病变时，我们建议将谱学纳入MR研究方案中。© 2023 作者发表，由Elsevier Inc.代表华盛顿大学出版。

Primary central nervous system (CNS) lymphoma is a very rare aggressive non-Hodgkin disease that originates in CNS (brain, leptomeninges, spinal cord, or eyes). It seems to have increased over the last two decades in both immunocompromised and immunocompetent patients. Primary large B-cell lymphoma involving the cerebellopontine angle (CPA) is extremely rare: only 15 cases of large B-cell lymphoma of the CPA have been reported worldwide; based on our knowledge, no cases studied with MR Spectroscopy. Primary large B-cell lymphoma of the CPA must be differentiated from other cerebellopontine angle diseases, such as acoustic neuroma and meningioma. An early and accurate diagnosis of this neoplasm is necessary for the best management because it is a radiosensitive and chemosensitive tumor. Herein, we report a rare case of B-cell lymphoma involving the left CPA in a 65-year-old man who presented with 3 months of hearing loss on the left, illustrated by MR and TC imaging, highlighting how the MR Spectroscopy, thanks to their greater specificity, is decisive in achieving the correct diagnosis of primary lymphoma and differentiating it from acoustic schwannoma or meningioma. Therefore, in the suspicion of a malignant heteroplastic lesion of the CPA, we suggest including Spectroscopy in the MR study protocol.© 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington.