研究动态
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弓形虫淋巴结炎 —— 一个两年时间内诊断出的8例病例系列:是一根稻草中的针吗?

Toxoplasmosis lymphadenopathy-A series of 8 cases diagnosed in a 2-year timeframe: Is it a needle in a haystack?

发表日期:2023 Sep
作者: Manasi Chetan Mundada, Faiq Ahmed, Snehil Kumar, Suseela Kodandapani, L M Chandrasekhara Rao
来源: Parasites & Vectors

摘要:

弓形虫病是由弓形虫(Toxoplasma gondii)引起的一种寄生虫传染病。感染的临床表现取决于患者的年龄和免疫状态。在免疫功能正常的患者中,其可能表现为非特异性淋巴结肿大和自限性疾病。相比之下,在免疫功能受损的患者中,这可能是一种危及生命的感染。我们在过去两年中在本机构诊断出了8例弓形虫淋巴结炎症。淋巴结肿大会引起恶性肿瘤的怀疑,但反应性淋巴结炎常常标志着诊断评估的结束。仔细的形态学评估和经典三联征常常能够指示出一个确定的诊断。我们在这里呈现一系列的病例,以引起对这种实体的关注,因为大部分已发表的文献都以病例报告和血清学调查的形式存在,很少有研究同时显示组织病理学和血清学。© Indian/Association of Otolaryngologists of India 2023. Springer Nature或其许可方(例如协会或其他合作伙伴)在与作者或其他权利持有人签订的出版协议下独家拥有本文的所有权;关于本文已接受的手稿版本的作者自行归档仅受此类出版协议和适用法律的规定约束。
Toxoplasmosis is a zoonosis caused by Toxoplasma gondii, an obligate intracellular parasite. Clinical presentation of infection depends on the age and immune status of the patient. In immunocompetent patient, it may present as a non-specific lymphadenopathy and self- limiting illness. In contrast, in immunocompromised patients it can be a life-threatening infection. We present a series of 8 cases of toxoplasma lymphadenitis diagnosed in our institute in last two years. Lymphadenopathy raises a suspicion of malignancy; however, diagnosis of reactive lymphadenitis often marks the end of diagnostic evaluation. Careful morphological evaluation, the classic triad, often can direct at a conclusive diagnosis. We are presenting a case series to draw attention to this entity as majority of the published literature is in the form of case report and serological surveys and very occasional study showing both the histopathology and serology in tandem.© Association of Otolaryngologists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.