在抗肿瘤治疗的第一年内，乳腺癌患者对体育活动的认识提高与身体健康的获得和体重的稳定有关：BEGYN-1研究。
Improved awareness of physical activities is associated with a gain of fitness and a stable body weight in breast cancer patients during the first year of antineoplastic therapy: the BEGYN-1 study.
发表日期：2023
作者：
Cosima Zemlin, Julia Theresa Schleicher, Laura Altmayer, Caroline Stuhlert, Carolin Wörmann, Marina Lang, Laura-Sophie Scherer, Ida Clara Thul, Lisanne Sophie Spenner, Jana Alisa Simon, Alina Wind, Elisabeth Kaiser, Regine Weber, Sybelle Goedicke-Fritz, Gudrun Wagenpfeil, Michael Zemlin, Georges Steffgen, Erich-Franz Solomayer, Carolin Müller
来源：
PHYSICAL THERAPY & REHABILITATION JOURNAL
摘要：
乳腺癌是女性中最常见的癌症。减少体力活动和超重与预后不良有关。乳腺癌患者在治疗期间容易体重增加、肌肉质量减少和体力活动减少。迫切需要概念来激励患者参与体力活动。本前瞻性观察性BEGYN-1研究包括了110名非转移性乳腺癌患者。治疗开始前和治疗一年期间每季度测量了生理参数和身体组成。患者在整个研究期间使用健身追踪器并记录他们的体力活动在活动日志中。尽管患者未接受任何有导向的运动，且在COVID-19大流行期间有限制条件，但他们增加了体力活动（代谢当量任务（MET）-分钟：p<0.001），身体健康状况改善（静息心率降低：p=0.001），且在研究期间没有体重增加（中位数-0.4kg）。加强对体力活动的认知与乳腺癌患者在治疗首年期间体力活动、身体健康状况的提高以及体重的稳定相关。诊断时的咨询应该激励患者参与体力活动，佩戴健身追踪器并记录活动。版权所有 © 2023 Zemlin, Schleicher, Altmayer, Stuhlert, Wörmann, Lang, Scherer, Thul, Spenner, Simon, Wind, Kaiser, Weber, Goedicke-Fritz, Wagenpfeil, Zemlin, Steffgen, Solomayer and Müller.
Breast cancer is the most frequent cancer in women. Reduced physical activity and overweight are associated with poor prognosis. Breast cancer patients have a high risk to gain weight, lose muscle mass and reduce physical activity during therapy. Concepts are urgently needed to motivate patients to engage in physical activity.110 non-metastatic breast cancer patients were included in the prospective observational BEGYN-1 study. Physiological parameters and body composition were measured before the start of therapy and then quarterly for one year. Patients used a fitness tracker and documented their physical activity in a diary throughout the study.Although the patients were not offered any guided exercise, and despite the restrictions during the COVID-19 pandemic, they increased their physical activity (metabolic equivalent of task (MET) -minutes): p<0.001), physical fitness (decreasing resting heart rate: p=0.001) and did not gain weight (median - 0.4kg) over the course of the study.Improved awareness of physical activity is associated with an increase in physical activity, fitness, and a stable weight during the first year of therapy in breast cancer patients. Counselling at diagnosis should motivate patients to engage in physical activity, wear a fitness tracker and document activities.Copyright © 2023 Zemlin, Schleicher, Altmayer, Stuhlert, Wörmann, Lang, Scherer, Thul, Spenner, Simon, Wind, Kaiser, Weber, Goedicke-Fritz, Wagenpfeil, Zemlin, Steffgen, Solomayer and Müller.